Modelling the Impact of Vaccination and Screening on the Dynamics of Human Papillomavirus Infection
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While human papillomavirus has been a recognized disease for a long time, the
control of outbreaks remains a challenge. The aim of this study is to investigate
the role of screening and vaccination as control strategies in curtailing the spread
of the disease. Using the next generation matrix, the disease free equilibrium has
be shown to be asymptotically stable. Furthermore, sensitivity analysis is then performed
on the key parameters driving HPV dynamics in order to detrmine their
relative importance and potential impact in HPV dynamics and to dertmine the
impacts of vaccination and screening in the spread of HPV. Numerical results indicate
that HPV infection can be reduced hwn both interventions, that is screenig
and vaccination, are implemented in order to reduce the burden of the disease.
Keywords
HPV infection, Screening, Reproduction number, Treatment, vaccination