| dc.creator |
Ndoile, Monica |
|
| dc.creator |
van Heerden, Fanie |
|
| dc.date |
2018-09-10T11:36:16Z |
|
| dc.date |
2018-09-10T11:36:16Z |
|
| dc.date |
2013 |
|
| dc.date.accessioned |
2021-05-03T13:19:55Z |
|
| dc.date.available |
2021-05-03T13:19:55Z |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/4869 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/4869 |
|
| dc.description |
The first total syntheses of ochnaflavone, an asymmetric biflavone consisting of apigenin and luteolin moieties, and the permethyl
ether of 2,3,2'',3''-tetrahydroochnaflavone have been achieved. The key steps in the synthesis of ochnaflavone were the formation of
a diaryl ether and ring cyclization of an ether-linked dimeric chalcone to assemble the two flavone nuclei. Optimal experimental
conditions for the oxidative cyclization to form ochnaflavone were established. |
|
| dc.subject |
biflavone |
|
| dc.subject |
diaryl ether |
|
| dc.subject |
natural products |
|
| dc.subject |
nucleophilic aromatic substitution |
|
| dc.subject |
ochnaflavone |
|
| dc.subject |
tetrahydroochnaflavone |
|
| dc.title |
Total Synthesis of Ochnaflavone |
|
| dc.type |
Journal Article, Peer Reviewed |
|