Tanzania Secondary Schools eLearning (TanSSe-L) system is one of the products of the ICT for eLearning research project conceived at the University of Dar es Salaam. The overall main objective of the e-learning project was to improve the quality of science education in secondary school in the rural areas of Tanzania by developing a tool to enable ICT support to rural secondary schools, by providing teaching materials, which are user friendly and facilitating self-learning and information sharing, starting with science and mathematics. This research work was based on three pillars; these are “establishment of suitable and effective connectivity and configuration”, development of a context centered platform which includes an e-learning management system using open source software” and “development of learning content materials for self-learning and sharing”. Development of a context centered platform which includes an e-learning management system using open source software was successfully developed and ended up having a TanSSe-L System, a Learning Management System (LMS) which allows for the creation and storage of learning materials, making them available, easily accessed and shareable among students from different secondary schools in Tanzania. TanSSe-L system was developed using a number of methodologies. This paper illustrates research methodologies used in developing a TanSSe-L system taking into consideration open source/low cost system, the issue of sustainability and the context of the application.