| dc.creator |
Macha, Innocent J |
|
| dc.creator |
Karacan, Ipek |
|
| dc.creator |
Ben-Nissan, Besim |
|
| dc.creator |
Cazalbou, Sophie |
|
| dc.creator |
Muller, Wolfgang H |
|
| dc.date |
2019-02-14T20:18:54Z |
|
| dc.date |
2019-02-14T20:18:54Z |
|
| dc.date |
2019-01 |
|
| dc.date.accessioned |
2021-05-07T08:00:12Z |
|
| dc.date.available |
2021-05-07T08:00:12Z |
|
| dc.identifier |
2523-3971 |
|
| dc.identifier |
http://hdl.handle.net/20.500.11810/5046 |
|
| dc.identifier |
doi.org/10.1007/s42452-018-0064-1 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.11810/5046 |
|
| dc.description |
While one of the major clinical and scientific challenges in the management of implant-related infections and post- operative complications after surgery is the application of new techniques, a new approach is pertinent in the design of medical implants to reduce bacterial infections. We have designed and tested antibiotic-containing biocomposite thin films of polylactic acid (PLA), and coralline-derived hydroxyapatite (HAp) as controlled drug delivery systems for the treatment of dental, orthopaedic and neural implant-related post-operative infections. These films can be applied to complicated designs of dental, miniaturized neural devices, cochlear or total hip replacement (THR) implants by spray or dip-coating techniques. Current results reveal that the devices could release antibiotic in a controlled manner to prevent significantly bacterial growth and biofilm production. Hydroxyapatite within the composites controls the release rate and also supplies minerals, such as calcium Ca2+ and phosphate PO42− ions, which are essential minerals for bone tissue regeneration. It is concluded from the physical, mechanical and biological properties that these coatings and devices could easily be utilized in a wide range of biomedical applications. |
|
| dc.language |
en |
|
| dc.publisher |
Springer NATURE |
|
| dc.subject |
Implant coating · Dental implant · Drug release · Antibiotic · Hydroxyapatite · Polymer composite · Biofilm · Post-operative infection · Cochlear devices · Neural devices |
|
| dc.title |
Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications |
|
| dc.type |
Journal Article |
|