This study aimed to identify key factors that have an influence on learners’ satisfaction with the e-learning system at the University of Dar es Salaam, Tanzania, using a modified, updated DeLone and McLean (D&M) (2003) model. The research model was tested against regression analysis using a sample of 153 enrolled students. The study found that system quality, instructor quality, and service quality had a significant positive effect on learners’ satisfaction, with service quality being the strongest predictor. However, course quality was found to have no significant effect on learners’ satisfaction with the e-learning system. The findings from this study will help institutions that are planning or implementing e-learning systems to enhance learners’ satisfaction and, consequently, increase systems success. The implications of these findings are discussed.