Dissertation (MSc Nursing Education)Introduction: Lack of nurses' job satisfaction and burnout in hospitals accelerate to low retention of workers. Unavailability of education opportunities is considered to be one of contributors of dissatisfaction and burnout among these nurses. Aim: This study intended to explore more on educational opportunities associated with job satisfaction and burnout among practicing nurses in Lake Zone. Methodology: Analytical quantitative cross-sectional study design was used. 416 Nurses were selected randomly and questionnaires were distributed for them in data collection with a response of 100%. Muller and McCloskey Satisfaction Scale (MMSS) (1990) was used for job satisfaction assessment. Prevalence of burnout inventory scale (Maslach, 1993) was also used. SPSS version 25 was used for data analysis. Results: Findings revealed that, 65.6 % of participants accepted that they have access to educational opportunities and 53% dissatisfied with their working health facilities followed by 47% who were satisfied. Likewise, on prevalence of burnout, indicated that 70.9% of respondents experienced lower level of emotional exhaustion. Moreover, results in personal accomplishment showed that, nurses were indicated higher level of burnout and lower level of depersonalization shown in practicing nurses in Lake Zone as well as a cardinal sign of burnout prevalence among them. Conclusion: Based on the study findings, it was concluded that lack of educational opportunities, job satisfaction and existance of burnout among practicing nurses in Lake Zone cause many problems. Study had shown that nurses in hospitals that investigated were not satisfied with their jobs as resulted into burnouts. However, study recommended that determinants of job dissatisfaction and burnout must be addressed for job retention and improvement by policymaker, hospital management and professional associations.