MA (Master of International Relations)The study was prompted by the overwhelming drug abusers in most streets of Dar-Es-Salaam in Tanzania. It focused on illicit drug trafficking and its negative impacts on youth, particularly in Kinondoni and Temeke districts. Drugs are trafficked through seaport found in Temeke district, and Kinondoni districts where most affected youth and drug dealers are found and conducted. All these districts are found in Dar-Es-Salaam region of Tanzania. A sample size of 70 respondents was employed so as to get relevant and reliable information concerning to the study and probability and non-probability sampling procedures was utilized to get this sample. Primary data and secondary data were utilized whereby social survey and interview used as method of data collection. As well questionnaire and interview schedule were utilized to get primary data and Data analysis both qualitative and quantitative were used whereby SPSS Version 16 also employed. The findings reveals that; there are lack of political will in fighting drug trafficking, poor security conditions, poor pay for security officers, poor management or supervision, corruption and involvement of high ranking government officials were categorized under factors significantly influencing drug trafficking in Temeke district and Kinondoni district. Besides, the study unveils that many youths in Dar-es-salaam engage in drug trafficking with numerous expectations which make them fall victims of drug trafficking and drug abuse. Lastly, the study findings also demonstrated that factors such as making huge sum of money in a very short time and becoming rich has made many youths victims of drug trafficking and drug abuse. The study recommends that all stakeholders especially policy makers and government should and ought to consider putting in place policies and strategies that will make people not to participate in this illicit trade in Kinondoni and Temeke districts and Tanzania as a whole. Consequently, the government must therefore have a political will, a coordinated efforts in its different organs, must pay well security officers especially Polices and provide them with economic incentives, cooperate with the civil society in fighting drug trafficking and drug abuse. These can make drug barons abstain from illicit drug trade in Tanzania.