Full Text Article. Also available at: https://doi.org/10.1111/tmi.13327The ARISE Network Adolescent Health Study is an exploratory, community‐based survey of 8075 adolescents aged 10–19 in 9 communities in 7 countries: Burkina Faso, Eswatini, Ethiopia, Ghana, Nigeria, Tanzania and Uganda. Communities were selected opportunistically and existing population cohorts maintained by health and demographic surveillance systems (HDSSs). The study is intended to serve as a first round of data collection for African adolescent cohorts, with the overarching goal of generating community‐based data on health‐related behaviours and associated risk factors in adolescents, to identify disease burdens and health intervention opportunities. Household‐based sampling frames were used in each community to randomly select eligible adolescents (aged 10–19 years). Data were collected between July 2015 and December 2017. Consenting participants completed face‐to‐face interviews with trained research assistants using a standardised questionnaire, which covered physical activity, cigarette and tobacco use, substance and drug use, mental health, sexual behaviours and practices, sexually transmitted infections, pregnancy, food security and food diversity, teeth cleaning and hand washing, feelings and friendship, school and home activities, physical attacks and injuries, health care, health status assessment and life satisfaction, as well as media and cell phone use and socio‐demographic and economic background characteristics. Results from this multi‐community study serve to identify major adolescent health risks and disease burdens, as well as opportunities for interventions and improvements through policy changes.