Integrative review of factors affecting cognitive health among older adults: perspectives on focus for prevention of dementia in developing countries

Masika, Golden Mwakibo; Yu, Doris S.F.

dc.creator	Masika, Golden Mwakibo
dc.creator	Yu, Doris S.F.
dc.date	2020-03-23T09:45:54Z
dc.date	2020-03-23T09:45:54Z
dc.date	2018
dc.date.accessioned	2022-10-20T14:01:35Z
dc.date.available	2022-10-20T14:01:35Z
dc.identifier	Masika, G. M., & Doris, S. F. (2018). Integrative review of factors affecting cognitive health among older adults: Perspectives on focus for prevention of dementia in developing countries. The Journal Of The Alzheimer's Association, 14(7), P976.
dc.identifier	https://doi.org/10.1016/j.jalz.2018.06.1309
dc.identifier	http://hdl.handle.net/20.500.12661/2295
dc.identifier.uri	http://hdl.handle.net/20.500.12661/2295
dc.description	Abstract. Full Text Article available at: https://aanddjournal.net/article/S1552-5260(18)31481-X/pdf
dc.description	Background: Cognitive impairment is a prominent public health issue among older adults. Different factors are believed to be associated with different stages of cognitive impairment. Knowledge of these factors are important in programming for preventive measures and to reduce worsening of impairment to more debilitating states. The aim of this integrative review and meta-analysis was to examine the modiﬁable risk factors impacting at different stages of cognitive impairment trajectory and their magnitude. Methods: A systematic search of literature was conducted in 6 databases: Medline, Embase, Global Health, Food Science and Technology Abstracts (FSTA), Co- chrane Central Register of Controlled Trials (CCRCT) and CI-NAHL complete, for current studies published within 10 years by November 2017. Prospective cohort, case control and cross sectional studied were included. Results: A total of 506 items were retrieved from the databases and 57 articles met the inclu- sion criteria for this review. Six groups of modiﬁable factors were identiﬁed including: vascular factors, co-morbidity and medical interventions, biological and nutritional factors, genetic and environmental interaction, psychological factors, life style factors and social factors. Vascular factors, particularly history of stroke presented the highest risk of dementia compared to the rest of other exposures, with odd ratios (OR) of ¼3.80 [95%CI, 1.92, 7.51]), and MCI (OR ¼1.82 [95% CI, 1.57, 2.11]), while engaging in physical activity at least 2 or more times per week was associated with a reduced risk of dementia (OR¼0.67 [95%CI, 0.48, 0.93]). Conclusions: Despite of some of vascular factors identiﬁed in this review are clinical conditions by themselves, their preventive measures are available in the developing countries. Culturally sensitive interventions focusing on vascular factors, as well as nutritional and life style factors may have dual positive effects in preventing both vascular condition and cognitive decline among elderly.
dc.language	en
dc.publisher	ELSEVIER
dc.subject	Cognitive impairment
dc.subject	Public health
dc.subject	Clinical conditions
dc.subject	Developing countries
dc.subject	Nutritional
dc.subject	Life style
dc.title	Integrative review of factors affecting cognitive health among older adults: perspectives on focus for prevention of dementia in developing countries
dc.type	Article