Clinical and histopathological profile of patients with prostate cancer in Kampala, Uganda

Yahaya, James J.

dc.creator	Yahaya, James J.
dc.date	2020-08-25T12:52:00Z
dc.date	2020-08-25T12:52:00Z
dc.date	2019
dc.date.accessioned	2022-10-20T14:01:36Z
dc.date.available	2022-10-20T14:01:36Z
dc.identifier	Yahaya, J. J. (2019). Clinical and histopathological profile of patients with prostate cancer in Kampala, Uganda. Medical Journal of Zambia, 46(1), 19-27.
dc.identifier	URL:https://www.ajol.info/index.php/mjz/article/view/186532
dc.identifier	http://hdl.handle.net/20.500.12661/2425
dc.identifier.uri	http://hdl.handle.net/20.500.12661/2425
dc.description	Full-text article. Also available at https://www.ajol.info/index.php/mjz/article/view/186532
dc.description	Prostate cancer (PCa) is the most prevalent malignancy among adult men with marked variation in mortality rate across regions globally. Uganda has the highest incidence of prostate cancer in East Africa. This study explored the spectrum of clinical and histopathological profile of patients diagnosed with PCa in Uganda between 2012 and 2014 at the Department of pathology, Makerere College of Health Sciences (Mak CHS). This was a descriptive cross-sectional study aimed at providing an update of the spectrum of clinical and histopathological profile of patients with PC in Uganda. The study involved 211 cases diagnosed at the department of pathology between 2012 and 2014. After obtaining ethical clearance to carry out the study from the school of biomedical science; laboratory requisition forms collected, were used to extract the biodata information and also selection of the cases. Having selected the cases by using non-probability approach, tissue blocks were retrieved from the archive of the laboratory, sectioned and stained with haemtoxylin and eosin stains and cover-slipped before being examined by the investigator. Data generated were entered in the data collection form and analysis for frequency and descriptive statistics was done using SPSS version 16.0. The study involved 211 patients with prostate cancer. The median age at diagnosis was 70 years and most of them, 82.9% had total PSA ≥ greater than 4.0ng/ml. Incomplete voiding of urine was the most common clinical feature which accounted for 43.6% and more than half, 61.2% of the patients had advanced disease. Almost half of the patients (44.6%) had Gleason score ≥ 8 and 47.9% of all the cases were in high risk group. Majority of patients with PCa in Uganda have raised pre-treatment total PSA and most of them are diagnosed with advanced disease. They also have high parameters of biologically aggressive prostate cancer such as Gleason score, lymphovascular invasion, perineural invasion and positive surgical margins.
dc.language	en
dc.publisher	Zambia Medical Association
dc.subject	Prostate cancer
dc.subject	Gleason score
dc.subject	Clinical stage
dc.subject	Uganda
dc.subject	Kampala
dc.subject	Cancer
dc.subject	Histopathology
dc.subject	PCa
dc.title	Clinical and histopathological profile of patients with prostate cancer in Kampala, Uganda
dc.type	Article