Dissertation (MM General Surgery)Background: The management of advanced and metastatic prostate cancer is more challenging in low income countries. Bilateral Orchidectomy is useful method in achieving surgical castration for treatment of prostate cancer in Tanzania. Little is known about its early outcome, and there is limited understanding of patients care outcomes, which have potential to improve quality of life of patients post-operatively. Objective: The main aim of this study was to determine early outcome following surgical castration for patients with prostate cancers at Benjamin Mkapa Hospital. Methodology: This was a hospital based prospective longitudinal study design among patients with prostate cancer who have undergone surgical castration and were attending clinic at Benjamin Mkapa hospital from July 2019 to May 2020. Structured questionnaire was used for data collection. Data were analyzed using SPSS Version 23.0. Numerical data have been summarized using mean and median with their measure of dispersion SD and IQR respectively. Cochrans Q test and Paired t-test was used as inferential statistics to determine the significant influence of surgical castration on prostate cancer. P value less than 0.05 was regarded as a statistical significance. Findings were presented using figures and tables. Results: A total of 131 men with prostate cancer who underwent surgical castration were analyzed. Their mean age was 74 years with standard deviation of 10 years, while 85.5% were elders aged 65 years and above. The median duration following post-surgical castration was 5 months with Intra quartile range of 4 to 6 months, and majority 87.0% (n=114) of the cases had duration of 4 to 6 months post-surgical castration. The results showed that among 131 patients with Prostate cancer in this study had significant decreased in Lower urinary tract symptoms [from 121(92.3%) to 26(19.8%), p<0.0001] symptoms of sexual dysfunction increases [from 127(96.9%) to 128.(97.7), p<0.014], metastatic symptoms [61.1% to 45.8%, p<0.0001], and Prostate specific antigen level from [116.18ng/mL to 64.92ng/mL, p<0.0001] following surgical castration. Conclusion: Surgical castration has positive influence on reduction of prostate specific antigen level, improvement in sexual function, decrease in lower urinary tract symptoms, and effective palliation of metastatic symptoms.