Prevalence and antibiotic susceptibility pattern of significant bacteriuria among pregnant women attending antenatal care at Makole health centre, Dodoma, Tanzania.

Baja, Abdallah Ramadhan

dc.creator	Baja, Abdallah Ramadhan
dc.date	2021-01-27T07:39:47Z
dc.date	2021-01-27T07:39:47Z
dc.date	2020
dc.date.accessioned	2022-10-20T14:03:20Z
dc.date.available	2022-10-20T14:03:20Z
dc.identifier	Baja, A. R. (2020). Prevalence and antibiotic susceptibility pattern of significant bacteriuria among pregnant women attending antenatal care at Makole health centre, Dodoma, Tanzania (Master dissertation). The University of Dodoma, Dodoma.
dc.identifier	http://hdl.handle.net/20.500.12661/2686
dc.identifier.uri	http://hdl.handle.net/20.500.12661/2686
dc.description	Dissertation (MMED Microbiology And Immunology)
dc.description	Introduction Significant bacteriuria during pregnancy can lead to serious obstetric complications, poor maternal and perinatal outcomes. The purpose of this study was to determine the prevalence and antibiotic susceptibility pattern of significant bacteriuria among pregnant women at Makole health centre Dodoma city, Tanzania. Methodology This was a cross sectional study conducted from February 2020 to April 2020. During this period two hundred consenting pregnant women, aged 18 years and above, at any gestation age were enrolled at Makole Health Centre. Mid-stream clean catch urine samples were collected and transported to Dodoma regional referral hospital laboratory in cool boxes packed with ice parks for microbiologic examination. Urine culture, identification tests and bacterial susceptibility pattern were done as per standard operating procedures and the clinical and laboratory standards institute (CLSI) standard guidelines. Chi squared tests and logistic regression were done to identify factors associated with asymptomatic bacteriuria. A p value < 0.05 was considered statistically significant. Results Out of 200 pregnant women studied, 24 (12%) had significant bacteriuria (mid-stream urine culture of at least 105 CFU/mL) in which Escherichia coli was the most prevalent isolated bacterium with 8 isolates (33.3%). Other isolated bacteria were Klebsiella species 1(4.1 %), Enterobacter species 1(4.1%), Pseudomonas aureginosa 1(4.1%), Streptococcus Species 1(4.1%), Coagulase negative Staphylococcus 6 (25%), and Staphylococcus aureus 6 (25%). Antimicrobial sensitivity test results showed that all 8 E. coli isolates were 100% sensitive to nitrofurantoin but they were 75% resistant to ceftriaxone. The 6 Staphylococci aureus isolates showed (100%), 83.3%, 66.7%, 66.7% and 50% resistance to penicillin, erythromycin, amoxicillin, cephalexin and Amoxicillin & clavulanic acid respectively. The 6 Coagulase negative Staphylococcus isolates were 100% resistant to amoxicillin and penicillin. Gestation age and previous history of UTI had statistically significant association for the development of bacteriuria among the study participants with p =value of 0.0472 and 0.0471 respectively. Conclusion The prevalence of significant bacteriuria among the study participants was high. Variable pattern of antibiotic resistance pattern was observed among bacterial urinary isolates with alarming levels to one of the first line recommended antibiotics in pregnancy, amoxicillin and clavulanic acid.These findings suggest for improved screening and treatment of pregnant women for significant bacteriuria to avert associated complications.
dc.language	en
dc.publisher	The University of Dodoma
dc.subject	Bacteriuria
dc.subject	Pregnant women
dc.subject	Antenatal care
dc.subject	Antibiotic susceptibility
dc.subject	Obstetric complications
dc.subject	Obstetrics
dc.subject	Maternal outcomes
dc.subject	Perinatal outcomes
dc.subject	Asymptomatic bacteriuria
dc.subject	Escherichia coli
dc.subject	Pseudomonas aureginosa
dc.subject	Urinary Tract Infection
dc.subject	UTI
dc.subject	Microorganism
dc.subject	Dodoma
dc.title	Prevalence and antibiotic susceptibility pattern of significant bacteriuria among pregnant women attending antenatal care at Makole health centre, Dodoma, Tanzania.
dc.type	Dissertation