Abstract Full text is available at https://doi.org/10.1080/03610918.2019.1702212This article develops the designing of two-stage process loss using neutrosophic statistics (NS). The neutrosophic operating characteristic for the two-stage sampling is developed under NS. Neutrosophic plan parameters are obtained using non-linear optimization using the neutrosophic statistical interval method for the constraints. A comparative study is carried out with the existing scheme. Some tables are provided and explained with an example under uncertainty.