Pattern, clinical characteristics, and outcome of meningitis among HIV-infected adults admitted in a tertiary hospital in North western Tanzania: a cross-sectional study

Boaz, Matobogolo M.; Kalluvya, Samuel; Downs, Jennifer A.; Mpondo, Bonaventura C. T.; Mshana, Stephen E.

dc.creator	Boaz, Matobogolo M.
dc.creator	Kalluvya, Samuel
dc.creator	Downs, Jennifer A.
dc.creator	Mpondo, Bonaventura C. T.
dc.creator	Mshana, Stephen E.
dc.date	2021-05-18T09:15:56Z
dc.date	2021-05-18T09:15:56Z
dc.date	2016
dc.date.accessioned	2022-10-20T14:01:43Z
dc.date.available	2022-10-20T14:01:43Z
dc.identifier	Boaz, M. M., Kalluvya, S., Downs, J. A., Mpondo, B. C., & Mshana, S. E. (2016). Pattern, clinical characteristics, and outcome of meningitis among HIV-infected adults admitted in a tertiary hospital in north western Tanzania: A cross-sectional study. Journal of tropical medicine, 2016.
dc.identifier	DOI: http://dx.doi.org/10.1155/2016/6573672
dc.identifier	http://hdl.handle.net/20.500.12661/3120
dc.identifier.uri	http://hdl.handle.net/20.500.12661/3120
dc.description	Full text article. Also available at http://dx.doi.org/10.1155/2016/6573672
dc.description	Limited information exists on the etiologies, clinical characteristics, and outcomes of meningitis among HIV-infected patients in Africa. We conducted a study to determine the etiology, clinical characteristics, and outcomes of meningitis among HIV-infected adults. Methods. A prospective cross-sectional hospital based study was conducted among HIV-infected patients aged ≥18 years admitted to the medical wards with symptoms and signs of meningitis. Sociodemographic and clinical information were collected using a standardized data collection tool. Lumbar puncture was performed to all patients; cerebrospinal fluid samples were sent for analysis. Among 60 HIV-infected adults clinically diagnosed to have meningitis, 55 had CSF profiles consistent with meningitis. Of these, 14 (25.5%) had a laboratory-confirmed etiology while 41 (74.5%) had no isolate identified. Cryptococcus neoformans was the commonest cause of meningitis occurring in 11 (18.3%) of patients followed by Mycobacterium tuberculosis (6.7%). The in-hospital mortality was 20/55 (36.4%). Independent predictors of mortality were low baseline CD4 count and turbid CSF appearance. Cryptococcal meningitis is the most prevalent laboratory-confirmed etiological agent among adult HIV-infected patients with suspected meningitis admitted to medical wards in Western Tanzania. Mortality rate in this population remains unacceptably high. Improving diagnostic capacity and early treatment may help to decrease the mortality rate
dc.language	en
dc.publisher	Hindawi Publishing Corporation
dc.subject	Meningitis
dc.subject	Adults HIV-infected
dc.subject	Mycobacterium tuberculosis
dc.subject	Tuberculosis
dc.subject	Cryptococcal meningitis
dc.subject	Human Immunodeficiency Virus
dc.subject	TB
dc.title	Pattern, clinical characteristics, and outcome of meningitis among HIV-infected adults admitted in a tertiary hospital in North western Tanzania: a cross-sectional study
dc.type	Article