Metaplastic carcinoma of breast: a report of two cases

Yahaya, James; Mremi, Alex

dc.creator	Yahaya, James
dc.creator	Mremi, Alex
dc.date	2021-05-24T06:39:44Z
dc.date	2021-05-24T06:39:44Z
dc.date	2020
dc.date.accessioned	2022-10-20T14:01:45Z
dc.date.available	2022-10-20T14:01:45Z
dc.identifier	Yahaya, J., & Mremi, A. (2020). Metaplastic carcinoma of breast: a report of two cases. Oxford Medical Case Reports, 2020(9).
dc.identifier	DOI: https://doi.org/10.1093/omcr/omaa070
dc.identifier	http://hdl.handle.net/20.500.12661/3176
dc.identifier.uri	http://hdl.handle.net/20.500.12661/3176
dc.description	Abstract. Full text article available at https://doi.org/10.1093/omcr/omaa070
dc.description	The pathogenesis of metaplastic breast carcinoma (MBC) is still debatable and it has been hypothesized that MBC develops as a result of transformation of epithelial cells into mesenchymal cells along with formation of a favorable tumor microenvironment. This favorable tumor microenvironment helps the transformed cells to undergo further mutations and clonal expansion. Case 1 was a 42-year old female with a 1-year history of a right breast fungating mass which was histologically confirmed to be matrix-producing type of MBC. Case 2 was a 47-year old female who presented with a recurrent left breast mass. Histologically, the tumor was confirmed to be carcinosarcomatous type of MBC. MBC is a rare, heterogeneous tumor with poor prognosis due to its aggressive behavior. It is more likely to mimic other benign breast conditions, therefore contributing to delay of diagnosis as it was for both of our patients herein presented.
dc.language	en
dc.publisher	Oxford University Press
dc.subject	Metaplastic
dc.subject	Carcinoma
dc.subject	Breast
dc.subject	Chondroid
dc.subject	Poor prognosis
dc.subject	Breast tumor
dc.subject	Metaplastic Breast Carcinoma
dc.subject	MBC
dc.subject	Breast chemotherapy
dc.subject	Tumor microenvironment
dc.title	Metaplastic carcinoma of breast: a report of two cases
dc.type	Article