Hypoglycaemic efficacy and phytochemical screening of fruits ethanolic extract of solanum terminaleforsk (solanaceae)

Kingo, Rajabu M.; Maregesi, Sheila M.; Kidukuli, Abdul W.

dc.creator	Kingo, Rajabu M.
dc.creator	Maregesi, Sheila M.
dc.creator	Kidukuli, Abdul W.
dc.date	2021-05-26T09:04:43Z
dc.date	2021-05-26T09:04:43Z
dc.date	2020
dc.date.accessioned	2022-10-20T13:09:28Z
dc.date.available	2022-10-20T13:09:28Z
dc.identifier	Kingo, R. M., Maregesi, S. M., & Kidukuli, A. W. (2020). Hypoglycaemic efficacy and phytochemical screening of fruits ethanolic extract of solanum terminale forsk (solanaceae). Issues Biol Sci Pharm Res, 8(2), 37-42.
dc.identifier	DOI: https://doi.org/10.15739/ibspr.20.004
dc.identifier	http://hdl.handle.net/20.500.12661/3232
dc.identifier.uri	http://hdl.handle.net/20.500.12661/3232
dc.description	Full text article. Also available at https://doi.org/10.15739/ibspr.20.004
dc.description	This study aimed at screening for the hypoglycaemic efficacy and phytochemical(s) of Solanum terminale fruits, being used traditionally in Lushoto, Tanzania for management of diabetes and hypertension. S. terminale fruits were collected November 2018 in Lushoto. Hypoglycaemic efficacy testing of the crude ethanolic extract and factions of S. terminale fruits at 100 mg/kg body weight (BW) dose were carried out in healthy albino mice using Oral Glucose Tolerance Test (OGTT). The phytochemical screening based on the chemical reactions of the precipitation and coloration with the standard reagents was used. The statistical analysis of results was carried out using independent student’s t-test (p ˂0.05).The crude ethanolic extract and fractions of S. terminale fruits at a dose of 100 mg/kg BW have demonstrated the significant blood glucose lowering efficacy, and the phytochemical screening indicated the presence of tannins, saponins, terpenoids, alkaloids, steroids, flavonoids and glycosides. Results of the study indicate the therapeutic potential of S. terminale fruits in the lowering of the blood glucose levels, but further studies are needed including toxicity and other animal models testing for diabetes.
dc.language	en
dc.publisher	Journal Issues International
dc.subject	Hypoglycaemic
dc.subject	Solanum terminale fruits
dc.subject	Phytochemical
dc.subject	Oral glucose tolerance test
dc.subject	Diabetes management
dc.subject	Diabetes mellitus
dc.subject	Lushoto
dc.subject	Tanzania
dc.subject	Plants
dc.subject	Metabolic disorder
dc.title	Hypoglycaemic efficacy and phytochemical screening of fruits ethanolic extract of solanum terminaleforsk (solanaceae)
dc.type	Article