| dc.creator |
Kilonzo, Semvua B. |
|
| dc.creator |
Gunda, Daniel W. |
|
| dc.creator |
Kashasha, Flora |
|
| dc.creator |
Mpondo, Bonaventura C. |
|
| dc.date |
2021-08-31T08:04:36Z |
|
| dc.date |
2021-08-31T08:04:36Z |
|
| dc.date |
2017 |
|
| dc.date.accessioned |
2022-10-20T14:01:49Z |
|
| dc.date.available |
2022-10-20T14:01:49Z |
|
| dc.identifier |
Kilonzo, S. B., Gunda, D. W., Kashasha, F., & Mpondo, B. C. (2017). Liver fibrosis and Hepatitis B coinfection among ART Naive HIV-infected patients at a tertiary level hospital in Northwestern Tanzania: a cross-sectional study. Journal of Tropical Medicine, 2017. |
|
| dc.identifier |
DOI:10.1155/2017/5629130 |
|
| dc.identifier |
http://hdl.handle.net/20.500.12661/3305 |
|
| dc.identifier.uri |
http://hdl.handle.net/20.500.12661/3305 |
|
| dc.description |
Full text article. Also available at https://doi.org/10.1155/2017/5629130 |
|
| dc.description |
Liver fibrosis which is a common complication of chronic hepatitis B infection is rarely diagnosed in low-resource countries due to limited capacity to perform biopsy studies. Data on the utilization of noninvasive techniques which are feasible for diagnosis of liver fibrosis in these settings among HIV-infected patients is scarce. The objective of this study was to establish the magnitude of liver fibrosis by using both aspartate-aminotransferase-to-platelets ratio and fibrosis-4 scores with associated hepatitis B coinfection among antiretroviral therapy naïve HIV-infected patients. We reviewed data of 743 adult patients attending HIV clinic with available hepatitis B surface antigen test results. Baseline clinical information was recorded and aspartate-aminotransferase-to-platelet ratio and fibrosis-4 scores were calculated. The cut-off values of 1.5 and 3.25 were used for diagnosis of significant fibrosis by aspartate-aminotransferase-to-platelets ratio and fibrosis-4 scores, respectively. Results. The prevalence of liver fibrosis was 3.5% when aspartate-aminotransferase-to-platelet score was used and 4.6% with fibrosis-4 score and they were both significantly higher among patients with hepatitis B coinfection. Younger patients with HIV advanced disease and elevated liver transaminases had increased risk of having hepatitis B coinfection. A remarkable number of HIV-infected patients present with liver fibrosis, predominantly those with hepatitis B infection. |
|
| dc.language |
en |
|
| dc.publisher |
Hindawi |
|
| dc.subject |
Fibrosis |
|
| dc.subject |
Liver fibrosis |
|
| dc.subject |
Hepatitis |
|
| dc.subject |
Hepatitis B coinfection |
|
| dc.subject |
ART naïve HIV-infected patients |
|
| dc.subject |
HIV-infected patients |
|
| dc.subject |
Antiretroviral therapy |
|
| dc.subject |
Hepatitis B virus |
|
| dc.subject |
HBV |
|
| dc.subject |
Liver fibrosis |
|
| dc.subject |
Chronic hepatitis |
|
| dc.subject |
Liver biopsy |
|
| dc.title |
Liver fibrosis and hepatitis B coinfection among ART Na\ve HIV-infected patients at a tertiary level hospital in Northwestern Tanzania: a cross-sectional study |
|
| dc.type |
Article |
|