Dose-response relationships in a microneutralization test for foot-and-mouth disease viruses
| dc.creator | Booth, J. C | |
| dc.creator | Rweyemamu, M. M | |
| dc.creator | Pay, T. W. F | |
| dc.date | 2022-05-06T11:09:41Z | |
| dc.date | 2022-05-06T11:09:41Z | |
| dc.date | 1977-05 | |
| dc.date.accessioned | 2022-10-25T08:50:17Z | |
| dc.date.available | 2022-10-25T08:50:17Z | |
| dc.description | Two-dimensional quantal microneutralization tests on foot-and-mouth disease viruses, in which neutralizing antibody activity was titrated against a serial range of virus doses, demonstrated a variety of dose-response curves some of which were rectilinear, others clearly curvilinear. Moreover, in the case of the non-linear responses obtained with some antisera, the shape of the curve was such that antibody titres recorded with doses of virus ranging from lCP-lO 5 TCD50 were closely similar. Studies were carried out on the effect of varying the con- ditions of the test on the shape of the dose-response curve: significant differences were obtained after treatment of the antiserum-virus mixtures with anti-species globulin, and when the test was assayed in cells of differing susceptibility to infection. | |
| dc.format | application/pdf | |
| dc.identifier | https://www.suaire.sua.ac.tz/handle/123456789/4056 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/90014 | |
| dc.language | en | |
| dc.subject | Microneutralization test | |
| dc.subject | Antiglobulin serum | |
| dc.subject | Foot-mouth disease viruses | |
| dc.title | Dose-response relationships in a microneutralization test for foot-and-mouth disease viruses | |
| dc.type | Article |