Borasio, G.D. et al. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2, 1087-1096

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dc.creatorBorasio, Gian D.
dc.creatorJohn, Jasson
dc.creatorWittinghofer, Alfred
dc.creatorBarde, Y. A.
dc.creatorSendtner, Michael
dc.creatorHeumann, Rolf
dc.date2016-07-14T20:56:10Z
dc.date2016-07-14T20:56:10Z
dc.date1989-01
dc.date.accessioned2021-05-03T13:29:43Z
dc.date.available2021-05-03T13:29:43Z
dc.descriptionAlthough evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the neuronal response to neurotrophic factors in nontransformed cells. We report here that the oncogene protein T24-ras, when introduced into the cytoplasm of freshly dissociated chick embryonic neurons, promotes the in vitro survival and neurite outgrowth of nerve growth factor-responsive dorsal root ganglion neurons, brain-derived neurotrophic factor-responsive nodose ganglion neurons, and ciliary neuronotrophic factor-responsive ciliary ganglion neurons. The proto-oncogene product c-Ha-ras also promotes neuronal survival, albeit less strongly. No effect could be observed with truncated counterparts of T24-ras and c-Ha-ras lacking the 23 C-terminal amino acids including the membrane-anchoring, palmityl-accepting cysteine. These results suggest a generalized involvement of ras or ras-like proteins in the intracellular signal transduction pathway for neurotrophic factors.
dc.identifierBorasio, G.D., John, J., Wittinghofer, A., Barde, Y.A., Sendtner, M. and Heumann, R., 1989. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron, 2(1), pp.1087-1096.
dc.identifierhttp://hdl.handle.net/20.500.11810/3224
dc.identifier10.1016/0896-6273(89)90233-X ยท Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/3224
dc.languageen
dc.titleBorasio, G.D. et al. ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons. Neuron 2, 1087-1096
dc.typeJournal Article, Peer Reviewed

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