Percutaneous Absorption of Dexamethasone3h in Rats and Mice: Comparative Study with Oral Administration

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dc.creatorJames, Makungu
dc.creatorMarty, J. P.
dc.date2016-06-15T20:51:41Z
dc.date2016-06-15T20:51:41Z
dc.date1976
dc.date.accessioned2018-03-27T08:54:28Z
dc.date.available2018-03-27T08:54:28Z
dc.descriptionFull text can be accessed at http://link.springer.com/article/10.1007/BF03189259
dc.descriptionPercutaneous absorption of dexamethasone in alcoholic solution in mice and rats was low. The permeability constant measured in mice was included between 1.05 and 1.39 × 10−5 cm/h. Beneath the area of application, a retention appeared in subcutaneous tissue and skeletal muscles which explained local pharmacological action. In other tissues (plasma, liver, kidneys, adrenals and muscles), the level of corticoid remained very low. In contrast, after oral administration, dexamethasone was present everywhere, whith the highest concentration in the liver and kidneys. Key-wordsPercutaneous absorption-dexamethasone SH-mice-rat
dc.identifierJames, M., Marty, J.P. and Wepierre, J., 1976. Percutaneous absorption of dexamethasone3H in rats and mice: comparative study with oral administration. European Journal of Drug Metabolism and Pharmacokinetics, 1(2), pp.69-72.
dc.identifierhttp://hdl.handle.net/20.500.11810/2463
dc.identifier10.1007/BF03189259
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2463
dc.languageen
dc.publisherSpringer Link
dc.subjectPercutaneous absorption
dc.subjectDexamethasone SH
dc.subjectMice
dc.subjectRat
dc.titlePercutaneous Absorption of Dexamethasone3h in Rats and Mice: Comparative Study with Oral Administration
dc.typeJournal Article

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