Microneutralization tests for serological typing and subtyping of foot-and-mouth disease virus strains

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dc.creatorRweyemamu, M. M
dc.creatorBooth, J. C
dc.creatorHead, Morwen
dc.creatorPay, T. W. F
dc.date.accessioned2022-05-17T11:35:39Z
dc.date.accessioned2025-08-05T07:29:43Z
dc.date.available2022-05-17T11:35:39Z
dc.date.created2022-05-17T11:35:39Z
dc.date.issued1977-12
dc.description.abstractA microneutralization test for serotyping of FMD viruses is described. It is based on earlier observations by Booth, Rweyemamu & Pay (1978) that dose-response relationships in quantal microneutralizations often deviated from linearity. The typing test described therefore utilizes undiluted virus preparations. In about 90 % of samples a positive typing was obtained in contrast with about 50 % for the complement fixation test. The test was also found to be susceptible to minimal quantities of heterotypic viral contamination. For strain differentiation the microneutralization test was carried out as a checkerboard test. When compared with the complement fixation test it was found to be more specific. The necessity to utilize virus-neutralization test systems for comparing FMD virus strains particularly for the purpose of vaccine selection is emphasized. The two dimensional microneutralization test has been applied to a study of comparing FMDV vaccine strains for Europe, South America, the Middle East and East Africa.
dc.identifierhttps://www.suaire.sua.ac.tz/handle/123456789/4149
dc.identifier.urihttp://repository.costech.or.tz/handle/20.500.14732/98157
dc.languageen
dc.subjectMicroneutralization
dc.subjectSerological typing
dc.subjectMouth disease virus
dc.subjectSubtyping
dc.titleMicroneutralization tests for serological typing and subtyping of foot-and-mouth disease virus strains
dc.typeArticle

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