Multifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants

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dc.creatorKaracan, Ipek
dc.creatorChou, Joshua
dc.creatorMacha, Innocent J
dc.creatorCazalbou, Sophie
dc.creatorMilthorpe, Bruce
dc.date2019-02-15T18:15:06Z
dc.date2019-02-15T18:15:06Z
dc.date2018-10
dc.date.accessioned2021-05-07T08:00:12Z
dc.date.available2021-05-07T08:00:12Z
dc.descriptionThe new novel implant designs include the functionality of advanced drug delivery systems in order to improve osteointegration and to inhibit the implant-related post-operative infections. In this research, Ti6Al4V metallic implants were coated with the multifunctional-dual slow drug delivery coating which includes a polymeric matrix system based on a poly-lactic acid thin film and a bioactive ceramic hydroxyapatite. This system consists of two different kinds of pharmaceuticals, which are gentamicin and simvastatin. It is reported in this paper that the simvastatin and gentamicin containing poly-lactic acid coating which was applied uniformly and successfully with and without hydroxyapatite microspheres. Most importantly, the release rate of drugs was controlled with PLA matrix and HAp microspheres which have different dissolution rates in order to prevent the high dosages causing adverse side-effects of drugs.
dc.identifierhttp://hdl.handle.net/20.500.11810/5055
dc.identifierdoi.org/10.4028/www.scientific.net/KEM.782.212
dc.identifier.urihttp://hdl.handle.net/20.500.11810/5055
dc.languageen
dc.publisherTrans Tech Publications Inc
dc.subjectControlled Drug Delivery System, Gentamicin, Hydroxyapatite, Metallic Implant Coating, Simvastatin
dc.titleMultifunctional-Dual Drug Delivery Poly-Lactic Acid Biocomposite Coating with Hydroxyapatite for Bone Implants
dc.typeJournal Article

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Department of Mechanical and Industrial Engineering