Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement

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dc.creatorShadrack, Daniel M.
dc.creatorMubofu, Egid B.
dc.creatorNyandoro, Stephen S.
dc.date2016-06-15T20:50:11Z
dc.date2016-06-15T20:50:11Z
dc.date2015
dc.date.accessioned2018-03-27T08:54:20Z
dc.date.available2018-03-27T08:54:20Z
dc.descriptionThe biomedical potential of flavonoids is normally restricted by their low water solubility. However, little has been reported on their encapsulation into polyamidoamine (PAMAM) dendrimers to improve their biomedical applications. Generation four (G4) PAMAM dendrimer containing ethylenediaminetetraacetic acid core with acrylic acid and ethylenediamine as repeating units was synthesized by divergent approach and used to encapsulate a flavonoid tetramethylscutellarein (TMScu, 1) to study its solubility and in vitro release for potential bioactivity enhancement. The as-synthesized dendrimer and the dendrimer–TMScu complex were characterized by spectroscopic and spectrometric techniques. The encapsulation of 1 into dendrimer was achieved by a co-precipitation method with the encapsulation efficiency of 77.8% ± 0.69% and a loading capacity of 6.2% ± 0.06%. A phase solubility diagram indicated an increased water solubility of 1 as a function of dendrimer concentration at pH 4.0 and 7.2. In vitro release of 1 from its dendrimer complex indicated high percentage release at pH 4.0. The stability study of the TMScu-dendrimer at 0, 27 and 40 °C showed the formulations to be stable when stored in cool and dark conditions compared to those stored in light and warmer temperatures. Overall, PAMAM dendrimer-G4 is capable of encapsulating 1, increasing its solubility and thus could enhance its bioactivity.
dc.identifierShadrack, D.M., Mubofu, E.B. and Nyandoro, S.S., 2015. Synthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement. International journal of molecular sciences, 16(11), pp.26363-26377.
dc.identifierhttp://hdl.handle.net/20.500.11810/2453
dc.identifier10.3390/ijms161125956
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2453
dc.languageen
dc.subjectPAMAM G4 dendrimer
dc.subjectEncapsulation
dc.subjectTetramethylscutellarein
dc.subjectSolubilization
dc.subjectIn vitro release
dc.subjectStability
dc.titleSynthesis of Polyamidoamine Dendrimer for Encapsulating Tetramethylscutellarein for Potential Bioactivity Enhancement
dc.typeJournal Article, Peer Reviewed

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