Phytochemical Constituents of Vangueria Infausta: Their Radical Scavenging and Antimicrobial Activities

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dc.creatorMbukwa, Elbert A.
dc.creatorChacha, Musa
dc.creatorMajinda, Runner R. T.
dc.date2016-06-15T20:55:00Z
dc.date2016-06-15T20:55:00Z
dc.date2007-01
dc.date.accessioned2018-03-27T08:54:31Z
dc.date.available2018-03-27T08:54:31Z
dc.descriptionA new biflavonoid, 5,7,3',5'',7'',4'''-hexahydroxy (4'-O-3''')-biflavone (1) and a polyketide derivative, methylcylohex-1-ene (3) [previously reported only as a synthetic compound] were isolated from aerial parts of Vangueria infausta. In addition, eight other known flavonoids viz. (-)-epicatechin, epiafzelechin, dihydrokaempferol, quercetin, luteolin (2), dihydroquercetin-3'-O-glucoside, daidzein and genistein were also isolated from this plant. Structures were identified using 1D-and 2D NMR experiments as well as ESI-MS, IR and UV spectra. The new biflavonoid 1 showed higher radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) reagent compared to ascorbic acid (standard) using a spectrophotometric method. Compound 1 was less sensitive to Gram-positive and Gram-negative bacterial strains and yeast (Candida mycoderma) compared to luteolin and quercetin on the Bioautographic Agar Overlay Assay.
dc.identifierMbukwa, E., Chacha, M. and Majinda, R.R., 2007. Phytochemical constituents of Vangueria infausta: their radical scavenging and antimicrobial activities. Arkivoc, 9, pp.104-112.
dc.identifierhttp://hdl.handle.net/20.500.11810/2495
dc.identifier10.3998/ark.5550190.0008.912
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2495
dc.languageen
dc.subjectVangueria infausta
dc.subjectFlavonoids
dc.subjectPolyketide derivative
dc.subjectDPPH
dc.subjectAntibacterial
dc.subjectAntifungal
dc.titlePhytochemical Constituents of Vangueria Infausta: Their Radical Scavenging and Antimicrobial Activities
dc.typeJournal Article, Peer Reviewed

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