Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications
| dc.creator | Macha, Innocent J | |
| dc.creator | Karacan, Ipek | |
| dc.creator | Ben-Nissan, Besim | |
| dc.creator | Cazalbou, Sophie | |
| dc.creator | Muller, Wolfgang H | |
| dc.date | 2019-02-14T20:18:54Z | |
| dc.date | 2019-02-14T20:18:54Z | |
| dc.date | 2019-01 | |
| dc.date.accessioned | 2021-05-07T08:00:12Z | |
| dc.date.available | 2021-05-07T08:00:12Z | |
| dc.description | While one of the major clinical and scientific challenges in the management of implant-related infections and post- operative complications after surgery is the application of new techniques, a new approach is pertinent in the design of medical implants to reduce bacterial infections. We have designed and tested antibiotic-containing biocomposite thin films of polylactic acid (PLA), and coralline-derived hydroxyapatite (HAp) as controlled drug delivery systems for the treatment of dental, orthopaedic and neural implant-related post-operative infections. These films can be applied to complicated designs of dental, miniaturized neural devices, cochlear or total hip replacement (THR) implants by spray or dip-coating techniques. Current results reveal that the devices could release antibiotic in a controlled manner to prevent significantly bacterial growth and biofilm production. Hydroxyapatite within the composites controls the release rate and also supplies minerals, such as calcium Ca2+ and phosphate PO42− ions, which are essential minerals for bone tissue regeneration. It is concluded from the physical, mechanical and biological properties that these coatings and devices could easily be utilized in a wide range of biomedical applications. | |
| dc.identifier | 2523-3971 | |
| dc.identifier | http://hdl.handle.net/20.500.11810/5046 | |
| dc.identifier | doi.org/10.1007/s42452-018-0064-1 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11810/5046 | |
| dc.language | en | |
| dc.publisher | Springer NATURE | |
| dc.subject | Implant coating · Dental implant · Drug release · Antibiotic · Hydroxyapatite · Polymer composite · Biofilm · Post-operative infection · Cochlear devices · Neural devices | |
| dc.title | Development of antimicrobial composite coatings for drug release in dental, orthopaedic and neural prostheses applications | |
| dc.type | Journal Article |