Flavonoids from Erythrina Schliebenii

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dc.creatorNyandoro, Stephen S.
dc.creatorMunissi, Joan J.E
dc.creatorKombo, Msim
dc.creatorMgina, Clarence A
dc.creatorPan, FangFang
dc.creatorGruhonjic, Amra
dc.creatorFitzpatrick, Paul A.
dc.creatorLu, Yu
dc.creatorWang, Bin
dc.creatorRissanen, Kari
dc.creatorErdelyi, Mate
dc.date2018-11-08T10:12:06Z
dc.date2018-11-08T10:12:06Z
dc.date2017-01-23
dc.date.accessioned2021-05-03T13:19:56Z
dc.date.available2021-05-03T13:19:56Z
dc.descriptionPrenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).
dc.descriptionSwedish Research Council (SRC)
dc.identifierFlavonoids from Erythrina schliebenii Stephen S. Nyandoro, Joan J. E. Munissi, Msim Kombo, Clarence A. Mgina, Fangfang Pan, Amra Gruhonjic, Paul Fitzpatrick, Yu Lu, Bin Wang, Kari Rissanen, and Máté Erdélyi Journal of Natural Products 2017 80 (2), 377-383 DOI: 10.1021/acs.jnatprod.6b00839
dc.identifierhttp://hdl.handle.net/20.500.11810/4970
dc.identifier10.1021/acs.jnatprod.6b00839
dc.identifier.urihttp://hdl.handle.net/20.500.11810/4970
dc.languageen
dc.publisherAmerican Chemical Society
dc.subjectFlavonoids, Erythrina schliebenii
dc.titleFlavonoids from Erythrina Schliebenii
dc.typeJournal Article, Peer Reviewed

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