Molecular Mechanism and Changes of Antioxidant Enzyme in ZnO Nanoparticles Against Fungus.

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dc.creatorZhang, Fengqin
dc.creatorLiu, Xiongduo
dc.creatorPentok, Myima
dc.creatorSauli, Elingarami
dc.creatorHe, Nongyue
dc.creatorZen, Xiangli
dc.creatorLi, Xiaolong
dc.creatorLiu, Tonghua
dc.date2020-07-10T07:32:15Z
dc.date2020-07-10T07:32:15Z
dc.date2019-04-01
dc.date.accessioned2022-10-25T09:20:44Z
dc.date.available2022-10-25T09:20:44Z
dc.descriptionThis research article published by Ingenta Connect, 2019
dc.descriptionAlthough zinc oxide nanoparticles are known as an effective antimicrobial agent, the mechanism for its antifungal activity has been assessed by only few studies. In this study, antifungal activity mechanism for ZnO via the change of physiology was explored. It was showed that the activities of SOD and CAT and the MDA content were increased significantly. The possible mechanisms were obtained that zinc oxide directly acts on the mycelium of to produce oxidative stress and destroy intracellular physiological balance. RNA-seq was then used to verify the conclusion obtained before, and obtained results suggested that the antifungal mechanism is attributed to oxidative stress and changes in membrane function.
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dc.identifierhttps://doi.org/10.1166/jbn.2019.2718
dc.identifierhttps://dspace.nm-aist.ac.tz/handle/20.500.12479/845
dc.identifier.urihttp://hdl.handle.net/123456789/95195
dc.languageen
dc.publisherIngenta Connect, 2020
dc.subjectAntifungal activity
dc.subjectPhysiological and Biochemical tests
dc.subjectRNA-SEQ
dc.titleMolecular Mechanism and Changes of Antioxidant Enzyme in ZnO Nanoparticles Against Fungus.

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