Ancistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1

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dc.creatorBringmann, Gerhard
dc.creatorDreyer, Michael
dc.creatorFaber, Johan H.
dc.creatorDalsgaard, Petur W.
dc.creatorStaerk, Dan
dc.creatorJaroszewski, Jerzy W.
dc.creatorNdangalasi, Henry J.
dc.creatorMbago, Frank M.
dc.creatorBrun, Reto
dc.creatorReichert, Matthias
dc.creatorMaksimenka, Katja
dc.creatorChristensen, Søren B.
dc.date2016-07-08T12:17:32Z
dc.date2016-07-08T12:17:32Z
dc.date2003-10
dc.descriptionFull text can be accessed at http://pubs.acs.org/doi/abs/10.1021/np030077b
dc.descriptionThe first phytochemical investigation of the recently discovered East African liana Ancistrocladus tanzaniensis is described, resulting in the isolation and structural elucidation of two new naphthylisoquinoline alkaloids, ancistrotanzanines A (5) and B (6), and the known compound ancistrotectoriline A (7). Ancistrotazanine A (5) represents a hitherto unprecedented 5,3'-coupling type between the naphthalene and isoquinoline portions, while 6 and 7 are 5,8'-coupled. The structures of the compounds were determined by spectroscopic, chemical, and chiroptical methods. Compounds 5 and 6 showed good activities against the pathogens of leishmaniasis and Chagas' disease, Leishmania donovani and Trypanosoma cruzi, while 5-7 displayed moderately potent antiplasmodial activities against Plasmodium falciparum parasites.
dc.identifierBringmann, G., Dreyer, M., Faber, J.H., Dalsgaard, P.W., Stærk, D., Jaroszewski, J.W., Ndangalasi, H., Mbago, F., Brun, R., Reichert, M. and Maksimenka, K., 2003. Ancistrotanzanine A, the First 5, 3'-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5, 8'-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis#, 1. Journal of natural products, 66(9), pp.1159-1165.
dc.identifierhttp://hdl.handle.net/20.500.11810/2901
dc.identifier10.1021/np030077b · Source: PubMed
dc.languageen
dc.titleAncistrotanzanine A, the First 5,3‘-Coupled Naphthylisoquinoline Alkaloid, and Two Further, 5,8‘-Linked Related Compounds from the Newly Described Species Ancistrocladus tanzaniensis # ,1
dc.typeJournal Article

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