The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells
| dc.creator | Shack, Leslie | |
| dc.creator | Buza, Joram | |
| dc.creator | Burgess, Shane | |
| dc.date | 2019-10-07T10:29:56Z | |
| dc.date | 2019-10-07T10:29:56Z | |
| dc.date | 2008-02-07 | |
| dc.date.accessioned | 2022-10-25T09:20:48Z | |
| dc.date.available | 2022-10-25T09:20:48Z | |
| dc.description | Research Article published by Springer-Verlag | |
| dc.description | Introduction Marek’s disease (MD), a herpesvirus-induced lymphoma of chickens is a unique natural model of CD30- overexpressing (CD30hi) lymphoma. We have previously proposed that the CD30hi neoplastically transformed CD4+ T cells in MD lymphomas have a phenotype antagonistic to cell mediated immunity. Here were test the hypothesis that the CD30hi neoplastically transformed MD lymphoma cells have a phenotype more closely resembling T-helper (Th)-2 or regulatory T (T-reg) cells. Materials and methods We separated ex vivo-derived CD30hi, from the CD30lo/¡ (non-transformed), MD lymphoma cells and then quantiWed the relative amounts of mRNA and proteins for cytokines and other genes that deWne CD4+ Th-1, Th-2 or T-reg phenotypes. Results and discussion Gene Ontology-based modeling of our data shows that the CD30hi MD lymphoma cells having a phenotype more similar to T-reg. Sequences that could be bound by the MD virus putative oncoprotein Meq in each of these genes’ promoters suggests that the MD herpesvirus may play a direct role in maintaining this T-reg-like phenotype. | |
| dc.format | application/pdf | |
| dc.identifier | https://doi 10.1007/s00262-008-0460-2 | |
| dc.identifier | http://dspace.nm-aist.ac.tz/handle/123456789/456 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/95250 | |
| dc.language | en | |
| dc.publisher | Springer-Verlag | |
| dc.subject | Regulatory T cell | |
| dc.subject | Gene Ontology | |
| dc.subject | Systems biology | |
| dc.subject | Animal model | |
| dc.title | The neoplastically transformed (CD30hi) Marek’s disease lymphoma cell phenotype most closely resembles T-regulatory cells | |
| dc.type | Article |