Morroniside cinnamic acid conjugate as an anti-inflammatory agent

Simple item page
dc.creatorTakeda, Yoshinori
dc.creatorTanigawa, Naomi
dc.creatorSunghwa, Fortunatus
dc.creatorNinomiya, Masayuki
dc.creatorHagiwara, Makoto
dc.creatorMatsushita, Kenji
dc.creatorKoketsu, Mamoru
dc.date2016-07-21T18:18:07Z
dc.date2016-07-21T18:18:07Z
dc.date2010-08
dc.date.accessioned2018-03-27T08:54:57Z
dc.date.available2018-03-27T08:54:57Z
dc.descriptionFull text can be accessed at http://www.sciencedirect.com/science/article/pii/S0960894X10008693
dc.descriptionA morroniside cinnamic acid conjugate was prepared and evaluated on E-selectin mediated cell-cell adhesion as an important role in inflammatory processes. 7-O-Cinnamoylmorroniside exhibited excellent anti-inflammatory activity (IC(50)=49.3 microM) by inhibiting the expression of E-selectin; further, it was more active than another cinnamic-acid-conjugated iridoid glycoside (harpagoside; IC(50)=88.2 microM), 7-O-methylmorroniside, and morroniside itself. As a result, 7-O-cinnamoylmorroniside was observed to be a potent inhibitor of TNF-alpha-induced E-selectin expression.
dc.identifierTakeda, Y., Tanigawa, N., Sunghwa, F., Ninomiya, M., Hagiwara, M., Matsushita, K. and Koketsu, M., 2010. Morroniside cinnamic acid conjugate as an anti-inflammatory agent. Bioorganic & medicinal chemistry letters, 20(16), pp.4855-4857.
dc.identifierhttp://hdl.handle.net/20.500.11810/3367
dc.identifier10.1016/j.bmcl.2010.06.095 ยท Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/3367
dc.languageen
dc.subjectMorroniside
dc.subject7-O-Cinnamoylmorroniside
dc.subjectAnti-inflammatory activity
dc.titleMorroniside cinnamic acid conjugate as an anti-inflammatory agent
dc.typeJournal Article

Files

Collections

Chemistry Department