Blood cytokine responses to early secreted protein antigen-6/culture filtrate protein-10 tuberculosis antigens 2 months after antituberculosis treatment among patients with drug-susceptible pulmonary tuberculosis.

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dc.creatorMvungi, Happiness
dc.creatorMbelele, Peter
dc.creatorBuza, Joram
dc.creatorMpagama, Stellah
dc.creatorSauli, Elingarami
dc.date2019-07-25T11:38:54Z
dc.date2019-07-25T11:38:54Z
dc.date2019-03-12
dc.date.accessioned2022-10-25T09:20:36Z
dc.date.available2022-10-25T09:20:36Z
dc.descriptionResearch Article published by Wolters Kluwer - Medknow Volume 8 | Issue 1 | January‑March 2019
dc.descriptionBackground: Human tuberculosis is a chronic inflammatory disease caused by mycobacterium tuberculosis. Pulmonary tuberculosis is the result of the failure of host immune system to control mycobacterium tuberculosis. The aim of the study was to asses the changes of the cytokines in active pulmonary tuberculosis patients before and after the use of anti-TB therapy. Methods: Multiple cytokine responses in active tuberculosis (TB) patients were investigated in this study following anti-TB drug therapy after 2 months. Ninety-six participants with pulmonary TB were engaged in the study between May 2018 and October 2018. Samples of blood were taken early before treatment at 0 and 2 months after using anti-TB therapy. The levels of interferon-gamma (IFN)-γ, interleukin-4 (IL-4), IL-6, IL-10, and tumor necrosis factor (TNF)-α in whole blood plasma collected from the QuantiFERON-TB Gold Plus were measured. Results: Compared with baseline levels, TNF-α, IL6 and IL10 were significantly lower following treatment whereas the IFN-γ and IL-4 increased significantly after treatment. The responses of five cytokines varied significantly after treatment (P < 0.0001) where IFN-γ was highest compared to other cytokines with 123.6%, AUC=0.757 and P < 0001, TNF-α AUC: 0.529 and P = 0.743, IL-4 AUC:0.557 and P = 0.514, IL-6 AUC:0.629 and P = 0.047, IL-10 AUC:0.549 and P = 0.581. Conclusion: It is concluded that changes of cytokines that observed during the treatment of TB patients play a very important role in monitoring pulmonary TB and can be suitable biomarkers to assess the effectiveness of anti-TB therapy in patients with TB.
dc.formatapplication/pdf
dc.identifier30860180
dc.identifierhttp://www.ijmyco.org/text.asp?2019/8/1/53/253964
dc.identifierhttp://dspace.nm-aist.ac.tz/handle/123456789/382
dc.identifier.urihttp://hdl.handle.net/123456789/95080
dc.languageen
dc.publisherWolters Kluwer - Medknow
dc.subjectAntituberculosis therapy
dc.subjectQuantiFERON-TB Gold Plus
dc.subjectBiomarkers
dc.subjectCytokines
dc.subjectPulmonary tuberculosis
dc.titleBlood cytokine responses to early secreted protein antigen-6/culture filtrate protein-10 tuberculosis antigens 2 months after antituberculosis treatment among patients with drug-susceptible pulmonary tuberculosis.
dc.typeArticle

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