Antimycobacterial and cytotoxicity evaluation of the constituents of Monodora carolinae

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dc.creatorMagoria, Nyangi
dc.creatorNyandoro, Stephen S.
dc.creatorMunissi, Joan J. E.
dc.creatorHeydenreichb, Matthias
dc.date2016-06-26T17:08:50Z
dc.date2016-06-26T17:08:50Z
dc.date2013
dc.date.accessioned2018-03-27T08:54:41Z
dc.date.available2018-03-27T08:54:41Z
dc.descriptionPhytochemical investigation of the stem bark of the recently described species Monodora carolinae (Annonaceae) afforded prenylindole derivatives (E)-4-(1H-indol-6-yl)-but-3-en-2-one (1), 5-formylindole (2), fatty acid (Z)-hexade-7-enoic acid (3) and the lignanamide cannabisin B (4). The structures of the isolated compounds were established using NMR and MS analyses. The antimycobacterial activities of the extracts and isolated compounds were evaluated against Mycobacterium madagascariense (MM) and M. indicus pranii (MIP) using the two-fold microtitre dilution method. While the extracts exhibited minimum inhibitory concentration (MIC) ranging from 500 – 1000 ìg/mL, the isolated compounds were 125 – 250 ìg/mL, indicating very low activity. Cytotoxic effects were evaluated using brine shrimp larvae whereby the ethanolic extract of the root bark exhibited the lowest LC50 (< 3ìg/mL). Isolation of prenylindole derivatives is of chemotaxonomic significance that affirms taxonomic placement of this plant species into the genus Monodora. This is the first time cannabisin B is reported from the genus Monodora.
dc.identifier0856 1761
dc.identifierhttp://hdl.handle.net/20.500.11810/2672
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2672
dc.languageen
dc.subjectMonodora carolinae
dc.subjectAnnonaceae
dc.subjectPrenylindole
dc.subjectCannabisin B
dc.subject(Z)-hexade-7-enoic acid
dc.subjectAntimycobacterial
dc.subjectCytotoxicity
dc.titleAntimycobacterial and cytotoxicity evaluation of the constituents of Monodora carolinae
dc.typeJournal Article, Peer Reviewed

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