Clinico-pathological profile of nasopharyngeal carcinoma at Muhimbili national hospital, Dares Salaam, Tanzania

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dc.creatorAbraham, Zephania Saitabau
dc.creatorMassawe, Enica Richard
dc.creatorNtunaguzi, Daudi
dc.creatorKahinga, Aveline Aloyce
dc.creatorYahaya, James Joseph
dc.creatorMithe, Siwillis Elizabeth
dc.date2020-11-24T10:23:39Z
dc.date2020-11-24T10:23:39Z
dc.date2019
dc.date.accessioned2022-10-20T14:01:38Z
dc.date.available2022-10-20T14:01:38Z
dc.descriptionFull text article. Also available at http://dx.doi.org/10.18203/issn.2454-5929.ijohns20192705
dc.descriptionBackground: Nasopharyngeal carcinoma (NPC) is an uncommon malignant tumor which has been reported invariably and cases have been encountered in Tanzania. Though rare they are associated with potential morbidity and mortality. The aim of this study was to characterize the clinico-pathological profile of such neoplasm in our set up. Methods: A retrospective review of 25 cases from hospital archives for 3 consecutive years was done where all patients with a histopathologically confirmed diagnosis of NPC were recruited. Data was analyzed using SPSS version 21. Results: Of the 25 eligible cases, 15 (60%) were males and 10 (40%) were females. Age range was 15-70 years. The peak age was 30-50 years in males and 50-59 years in females. Highest incidence was in the 5th decade. The commonest presenting features were cervical lymphadenopathy (92%) epistaxis (80%), hearing loss (80%) and nasal obstruction (76%) while the least common feature was seizures (4%). Histologically, undifferentiated carcinoma (76%) was the commonest variant while the least common one was differentiated non keratinizing squamous cell carcinoma (8%). Identifiable risk factors were consumption of salted smoked fish (80%), tobacco use (60%), alcohol intake (52%) and occupational exposure to wood dust (32%). Majority of patients (80%) were diagnosed with advanced stage of the disease (Stage IV). Conclusions: Findings from this study correlate with what has been reported elsewhere. Clinicians should have a higher index of suspicion in diagnosing NPC to enable early referral and prompt treatment of such malignant neoplasm.
dc.identifierAbraham, Z. S., Massawe, E. R., Ntunaguzi, D., Kahinga, A. A., Yahaya, J. J., & Mithe, S. E. (2019). Clinico-pathological profile of nasopharyngeal carcinoma at Muhimbili national hospital, Dares Salaam, Tanzania. International Journal of Otorhinolaryngol Head Neck Surgery, 5, 922-5.
dc.identifierDOI:10.18203/issn.2454-5929.ijohns20192705
dc.identifierhttp://hdl.handle.net/20.500.12661/2532
dc.identifier.urihttp://hdl.handle.net/20.500.12661/2532
dc.languageen
dc.publisherScientific Research Publishing
dc.subjectNasopharyngeal carcinoma
dc.subjectNPC
dc.subjectCarcinoma
dc.subjectNasopharynx
dc.subjectClinico-pathological profile
dc.subjectPathological profile
dc.subjectClinical profile
dc.subjectMalignant tumor
dc.subjectTanzania
dc.titleClinico-pathological profile of nasopharyngeal carcinoma at Muhimbili national hospital, Dares Salaam, Tanzania
dc.typeArticle

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