Immune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infections

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dc.creatorMarandu, Thomas F.
dc.creatorOduro, Jennifer D.
dc.creatorBorkner, Lisa
dc.creatorDekhtiarenko, Iryna
dc.creatorUhrlaub, Jennifer
dc.creatorDrabig, Anja
dc.creatorKröger, Andrea
dc.creatorZugich, Janko N.
dc.creatorSain, Luka C.
dc.date2016-07-08T07:23:54Z
dc.date2016-07-08T07:23:54Z
dc.date2015-09
dc.date.accessioned2018-04-18T10:54:01Z
dc.date.available2018-04-18T10:54:01Z
dc.descriptionLatent herpesvirus infections alter the immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse CMV, HSV-1 and/or MHV-68 with Influenza, WNV or VSV. We observed no increase in mortality or weight-loss over herpesvirus-negative counterparts and a relative, but no absolute reduction in CD8 responses against acute infections. Therefore, herpesviruses do not appear to increase susceptibility to emerging infections in aging. Copyright © 2015, American Society for Microbiology. All Rights Reserved
dc.identifierMarandu, T.F., Oduro, J.D., Borkner, L., Dekhtiarenko, I., Uhrlaub, J.L., Drabig, A., Kröger, A., Nikolich-Zugich, J. and Cicin-Sain, L., 2015. Immune protection against virus challenge in aging mice is not affected by latent herpesviral infections. Journal of virology, 89(22), pp.11715-11717.
dc.identifierhttp://hdl.handle.net/20.500.11810/2837
dc.identifier10.1128/JVI.01989-15 · Source: PubMed
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2837
dc.languageen
dc.subjectImmune Protection
dc.subjectLatent Herpesviral
dc.titleImmune Protection against Virus Challenge in Aging Mice Is Not Affected By Latent Herpesviral Infections
dc.typeJournal Article, Peer Reviewed

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