Effects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix

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dc.creatorMlalila, Nichrous
dc.creatorSwai, Hulda
dc.creatorKalombo, Lonji
dc.creatorHilonga, Askwar
dc.date2019-05-17T12:55:47Z
dc.date2019-05-17T12:55:47Z
dc.date2014-01-01
dc.date.accessioned2022-10-25T09:20:31Z
dc.date.available2022-10-25T09:20:31Z
dc.descriptionResearch Article published by Devo Press Journal
dc.descriptionThe goal of this study was to explore the effects of spray-drying on w/o/w double emulsions of methyltestosterone (MT) loaded in a stearic acid matrix. MT-loaded nanoparticles were formulated by a water-in-oil-in-water emulsion technique using 50, 75, and 100 mg of stearic acid, 2% and 3% w/v polyvinyl alcohol, 5% w/v lactose, and 0.2% w/v chitosan. The emulsions were immediately spray-dried based on an optimized model of inlet temperature and pump rate, and characterized for optimized responses with regard to particle size, polydispersity index, and zeta potential, for both emulsion and powder samples. Dynamic light scattering analysis shown that the nanoparticles increased in size with increasing concentrations of polyvinyl alcohol and stearic acid. Scanning electron microscopy indicated that the MT-loaded nanoparticles were spherical in shape, had a smooth surface, and were in an amorphous state, which was confirmed by differential scanning calorimetry. These MT-loaded nanoparticles are a promising candidate carrier for the delivery of MT; however, further studies are needed in order to establish the stability of the system and the cargo release profile under normal conditions of use.
dc.formatapplication/pdf
dc.identifierhttp://dspace.nm-aist.ac.tz/handle/123456789/77
dc.identifier.urihttp://hdl.handle.net/123456789/95013
dc.languageen_US
dc.subjectdouble emulsions
dc.subjectspray-drying
dc.subjectnanoparticles
dc.titleEffects of spray-drying on w/o/w multiple emulsions prepared from a stearic acid matrix
dc.typeArticle

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