Clinical predictors of malaria, acute bacterial meningitis and treatment outcomes among febrile children admitted with altered mental status in Northwestern Tanzania

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dc.creatorJumanne, Shakilu
dc.creatorMeda, John
dc.creatorHokororo, Adolfine
dc.creatorLeshabari, Kelvin
dc.date2020-03-24T11:34:23Z
dc.date2020-03-24T11:34:23Z
dc.date2017
dc.date.accessioned2022-10-20T14:01:34Z
dc.date.available2022-10-20T14:01:34Z
dc.descriptionFull Text Article. Also available at: https://academic.oup.com/tropej/article/64/5/426/4682722
dc.descriptionBackground: Malaria and acute bacterial meningitis (ABM) are the leading infectious causes of febrile encephalopathy in malaria endemic settings. The clinical distinction of the two conditions is complicated by overlap in clinical features. Objective: To determine the clinical predictors for malaria, ABM and treatment outcome in febrile children aged 2 months to 12 years with altered mentation at two tertiary hospitals in Northwestern Tanzania. Methods: Prospective study of 103 children to document demographic data and physical examination findings, such as level of consciousness and meningeal irritations. Laboratory results for cerebrospinal fluid, hemoglobin, malaria and HIV were also evaluated. Results: Age>60 months and hemoglobin 5 g/dl were independent predictors of malaria; (p¼0.013 and 0.004, respectively). HIV infection was the only predictor of meningitis, p¼0.037, and mortality was high if the diagnosis was unconfirmed. Conclusions: Children with febrile encephalitic are more likely to have malaria than ABM if they have severe anemia.
dc.identifierJumanne, S., Meda, J., Hokororo, A., & Leshabari, K. (2018). Clinical predictors of malaria, acute bacterial meningitis and treatment outcomes among febrile children admitted with altered mental status in northwestern Tanzania. Journal of Tropical Pediatrics, 64(5), 426-433
dc.identifierhttp://hdl.handle.net/20.500.12661/2338
dc.identifier.urihttp://hdl.handle.net/20.500.12661/2338
dc.languageen
dc.publisherOxford University Press
dc.subjectMalaria
dc.subjectMeningitis
dc.subjectFebrile encephalopathy
dc.subjectComa
dc.subjectAcute bacterial meningitis
dc.subjectAnemia
dc.subjectHIV
dc.subjectHuman Immunodeficiency Virus
dc.subjectHIV infection
dc.titleClinical predictors of malaria, acute bacterial meningitis and treatment outcomes among febrile children admitted with altered mental status in Northwestern Tanzania
dc.typeArticle

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