Antimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.

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dc.creatorSubbiah, Murugan
dc.creatorCaudell, Mark
dc.creatorMair, Colette
dc.creatorDavis, Margaret
dc.creatorMatthews, Louise
dc.creatorQuinlan, Robert
dc.creatorQuinlan, Marsha
dc.creatorLyimo, Beatus
dc.creatorBuza, Joram
dc.creatorKeyyu, Julius
dc.creatorCall, Douglas
dc.date2020-01-16T09:30:05Z
dc.date2020-01-16T09:30:05Z
dc.date2020-01-13
dc.date.accessioned2022-10-25T09:20:27Z
dc.date.available2022-10-25T09:20:27Z
dc.descriptionThe research article published on Nature Communications 2020
dc.descriptionAntibiotic use and bacterial transmission are responsible for the emergence, spread and persistence of antimicrobial-resistant (AR) bacteria, but their relative contribution likely differs across varying socio-economic, cultural, and ecological contexts. To better understand this interaction in a multi-cultural and resource-limited context, we examine the distribution of antimicrobial-resistant enteric bacteria from three ethnic groups in Tanzania. Household-level data (n = 425) was collected and bacteria isolated from people, livestock, dogs, wildlife and water sources (n = 62,376 isolates). The relative prevalence of different resistance phenotypes is similar across all sources. Multi-locus tandem repeat analysis (n = 719) and whole-genome sequencing (n = 816) of Escherichia coli demonstrate no evidence for host-population subdivision. Multivariate models show no evidence that veterinary antibiotic use increased the odds of detecting AR bacteria, whereas there is a strong association with livelihood factors related to bacterial transmission, demonstrating that to be effective, interventions need to accommodate different cultural practices and resource limitations.
dc.formatapplication/pdf
dc.identifier31932601
dc.identifierhttps://doi.org/10.1038/s41467-019-13995-5
dc.identifierhttp://dspace.nm-aist.ac.tz/handle/123456789/527
dc.identifier.urihttp://hdl.handle.net/123456789/94944
dc.languageen
dc.publisherNature Communications
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 International
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectAntimicrobial resistance
dc.subjectDeveloping world
dc.subjectEpidemiology
dc.subjectResearch Subject Categories::NATURAL SCIENCES
dc.titleAntimicrobial resistant enteric bacteria are widely distributed amongst people, animals and the environment in Tanzania.
dc.typeArticle

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