Clinicopathological findings of retinoblastoma: A 10-Year experience from a tertiary hospital in Kampala, Uganda

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dc.creatorYahaya, James J
dc.creatorRugwizangoga, Belson
dc.creatorMremi, Alex
dc.creatorMunema, Asafu
dc.date2020-08-25T08:47:31Z
dc.date2020-08-25T08:47:31Z
dc.date2019
dc.date.accessioned2022-10-20T14:01:36Z
dc.date.available2022-10-20T14:01:36Z
dc.descriptionFull Text Article also available at https://doi.org/10.1155/2019/5829284
dc.descriptionRetinoblastoma (RB) is one of the most common cancers occurring in young children in sub-Saharan Africa. The incidence rate reported in the literature is 9,000 new cases per year, which corresponds to 1 in 15,000 births. This study aimed at analyzing the clinicopathological findings in children with RB in Uganda. Purpose. The purpose of this study was to describe and analyze the clinicopathological findings in the patients with RB Design. This was a cross-sectional analytical study involving 234 eyeball surgical specimens from 214 patients with RB diagnosed between January 2006 and December 2015. Results. The mean age of the patients was 27.8 months (SD = 21.413, range: 1–132 months). More than half of the cases, 50.9%, presented with leukocoria. Invasion of choroid, sclera, anterior chamber, and optic nerve was found in 26.5% (n = 58), 51.2% (n = 88), 26.2% (n = 45), and 29.2% (n = 49), respectively. Twenty-six percent (n = 56) of the cases with intraocular tumour were at stage I and all patients with metastasis 4.7% (n = 11) had stage IV. The correlation between postlaminar optic nerve invasion and massive choroidal invasion was statistically significant (p=0.002). Also, there was a statistical significance difference between metastasis and post laminar invasion (p=0.004). The majority of children with RB in Uganda present clinically with leucokoria, and their parents or guardians seek medical intervention at a later stage. Moreover, there was a noticeably significant lag period for the patients to begin treatment after the diagnosis was done.
dc.identifierYahaya, J. J., Rugwizangoga, B., Mremi, A., & Munema, A. (2019). Clinicopathological Findings of Retinoblastoma: A 10-Year Experience from a Tertiary Hospital in Kampala, Uganda. Journal of ophthalmology, 2019.
dc.identifierDOI: 10.1155/2019/5829284
dc.identifierhttp://hdl.handle.net/20.500.12661/2409
dc.identifier.urihttp://hdl.handle.net/20.500.12661/2409
dc.languageen
dc.publisherHindawi
dc.subjectRetinoblastoma
dc.subjectRB
dc.subjectCancer
dc.subjectUganda
dc.subjectKampala
dc.subjectYoung children
dc.subjectSub- Saharan Africa
dc.subjectClinicopathology
dc.subjectLeukocoria
dc.subjectEye cancer
dc.titleClinicopathological findings of retinoblastoma: A 10-Year experience from a tertiary hospital in Kampala, Uganda
dc.typeArticle

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