Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis

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dc.creatorAronsson, Per
dc.creatorMunissi, Joan J. E.
dc.creatorGruhonjic, Amra
dc.creatorFitzpatrick, Paul A.
dc.creatorLandberg, Göran
dc.creatorNyandoro, Stephen S.
dc.creatorErdélyi, Máté
dc.date2016-06-26T17:09:05Z
dc.date2016-06-26T17:09:05Z
dc.date2016-01-15
dc.date.accessioned2018-03-27T08:54:36Z
dc.date.available2018-03-27T08:54:36Z
dc.descriptionAs part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8′-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3′-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520–82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1–5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.
dc.identifierAronsson, P., Munissi, J., Gruhonjic, A., Fitzpatrick, P., Landberg, G., Nyandoro, S., & Erdelyi, M. (2016). Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis. Diseases, 4(1), 3. http://dx.doi.org/10.3390/diseases4010003
dc.identifierhttp://hdl.handle.net/20.500.11810/2678
dc.identifier10.3390/diseases4010003
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2678
dc.languageen
dc.publisherMDPI
dc.subjectDiospyros shimbaensis
dc.subjectEbenaceae
dc.subjectTetralones
dc.subjectNaphthoquinoes
dc.subjectRadical scavenging
dc.subjectCytotoxicity
dc.subjectMDA-MB-231
dc.subjectDPPH
dc.titlePhytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis
dc.typeJournal Article, Peer Reviewed

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