New Antimicrobial, Mosquito Larvicidal and Other Metabolites from Two Artabotrys Species

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dc.creatorNyandoro, Stephen S.
dc.creatorJoseph, Cosam C.
dc.creatorNkunya, Mayunga H. H.
dc.creatorHosea, Ken M.
dc.date2016-06-26T17:12:36Z
dc.date2016-06-26T17:12:36Z
dc.date2013
dc.date.accessioned2018-03-27T09:00:35Z
dc.date.available2018-03-27T09:00:35Z
dc.descriptionFull text can be accessed at http://www.tandfonline.com/doi/abs/10.1080/14786419.2012.725397
dc.descriptionAzabicycloheptenoylditerpene 1-((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyl)-2-azabicyclo[2.2.1]hept-5-en-3-one (artamodamide, 1), diphenylpentanoid (E)-1,5-bis(4-hydroxyphenyl)-pent-1-en-3-one (artamenone, 2) and N-methoxy-5-oxoaporphinoid (artamonteirine, 3) were isolated as new metabolites from Artabotrys modestus Diels ssp macranthus Verdc. and Artabotrys monteiroae Oliv. (Annonaceae), together with several known compounds. Structures of the isolated compounds were established based on analysis of their spectroscopic data. Some of the compounds exhibited antimicrobial activity (minimum inhibitory concentration values between 2.5 and 20 µg mL−1) and varying levels of mosquito larvicidal potency. These results further indicate the versatility of the family Annonaceae in accumulating bioactive natural products with diverse chemical structures and wide spectra of biological activities, and hence suggesting the need to conserve Annonaceae species that are potentially vulnerable to extinction.
dc.identifierNyandoro, S.S., Joseph, C.C., Nkunya, M.H. and Hosea, K.M., 2013. New antimicrobial, mosquito larvicidal and other metabolites from two Artabotrys species. Natural product research, 27(16), pp.1450-1458.
dc.identifierhttp://hdl.handle.net/20.500.11810/2711
dc.identifier10.1080/14786419.2012.725397
dc.identifier.urihttp://hdl.handle.net/20.500.11810/2711
dc.languageen
dc.publisherTaylor & Francis
dc.subjectAnnonaceae
dc.subjectArtabotrys modestus
dc.subjectArtabotrys monteiroae
dc.subjectAzabicycloheptenoylditerpene
dc.subjectDiphenylpentanoid
dc.subjectN-methoxy-5-oxoaporphinoid
dc.subjectAntimicrobial
dc.subjectLarvicidal
dc.titleNew Antimicrobial, Mosquito Larvicidal and Other Metabolites from Two Artabotrys Species
dc.typeJournal Article

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