Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles.
| dc.creator | Omwoyo, Wesley | |
| dc.creator | Melariri, Paula | |
| dc.creator | Gathirwa, Jeremiah | |
| dc.creator | Oloo, Florence | |
| dc.creator | Mahanga, Geoffrey | |
| dc.creator | Kalombo, Lonji | |
| dc.creator | Ogutu, Bernhards | |
| dc.creator | Swai, Hulda | |
| dc.date | 2019-10-16T09:00:19Z | |
| dc.date | 2019-10-16T09:00:19Z | |
| dc.date | 2016-04-01 | |
| dc.date.accessioned | 2022-10-25T09:20:43Z | |
| dc.date.available | 2022-10-25T09:20:43Z | |
| dc.description | Research Article published by Elsevier Volume 12, Issue 3, April 2016 | |
| dc.description | Effective use of dihydroartemisinin (DHA) is limited by poor water-solubility, poor pharmacokinetic profile and unsatisfactory clinical outcome especially in monotherapy. To reduce such limitations, we reformulated DHA into solid lipid nanoparticles (SLNs) as a nanomedicine drug delivery system. DHA-SLNs were characterized for physical parameters and evaluated for in vitro and in vivo antimalarial efficacy. DHA-SLNs showed desirable particle characteristics including particle size (240.7 nm), particle surface charge (+ 17.0 mV), drug loadings (13.9 wt %), encapsulation efficacy (62.3%), polydispersity index (0.16) and a spherical appearance. Storage stability up to 90 days and sustained release of drug over 20 h was achieved. Enhanced in vitro (IC50 0.25 ng/ml) and in vivo (97.24% chemosuppression at 2 mg/kg/day) antimalarial activity was observed. Enhancement in efficacy was 24% when compared to free DHA. These encouraging results show potential of using the described formulation for DHA drug delivery for clinical application. | |
| dc.format | application/pdf | |
| dc.identifier | 26724538 | |
| dc.identifier | https://doi.org/10.1016/j.nano.2015.11.017 | |
| dc.identifier | http://dspace.nm-aist.ac.tz/handle/123456789/492 | |
| dc.identifier.uri | http://hdl.handle.net/123456789/95186 | |
| dc.language | en | |
| dc.publisher | Elsevier | |
| dc.subject | Dihydroartemisinin | |
| dc.subject | Nanomedicine drug delivery | |
| dc.subject | Solid lipid nanoparticles | |
| dc.title | Development, characterization and antimalarial efficacy of dihydroartemisinin loaded solid lipid nanoparticles. | |
| dc.type | Article |