Preliminary in vivo antitrypanosomal activity and cytotoxicity of Entada abyssinica, Securinega virosa and Ehretia amoena

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dc.creatorSempombe, Joseph
dc.creatorMugoyela, Veronica
dc.creatorMihale, Matobola Joel
dc.creatorZacharia, Abdallah
dc.creatorIpagala, Pius
dc.creatorKilulya, Kessy Fidel
dc.date2018-10-04T12:27:29Z
dc.date2018-10-04T12:27:29Z
dc.date2014
dc.date.accessioned2021-05-03T13:19:56Z
dc.date.available2021-05-03T13:19:56Z
dc.descriptionEntada abyssinica, Securinega virosa and Ehretia amoena are traditionally used in Southern Uganda to treat Human African Trypanosomiasis (HAT). Extracts from the roots and root barks of E. abyssinica, S. virosa and E. amoena were investigated for in vivo antitrypanosomal activity against Trypanosoma brucei brucei in mice. The extracts were also tested in vitro for potential cytotoxicity against a 3-cell line panel consisting of TK10 (renal), UACC62 (melanoma) and MCF7 (breast) cancer cells using the highly sensitive Sulforhodamine B assay. The ethanolic extract from the roots of E. abyssinica showed a reduction of T. b. brucei parasitaemia at a single dose of 400 mg/kg. The petroleum ether extract from the root bark of E. abyssinica showed the highest cytotoxicity with GI50, total growth inhibition, LC50 and LC100 values of less than 6.25 µg/ml. Our findings confirm earlier in vitro antitrypanosomal studies and lend credence to the traditional use of these plants against trypanosomiasis.
dc.identifierSempombe, Joseph & Mugoyela, Veronica & Mihale, Matobola & Zacharia, Abdallah & Ipagala, Pius & Kessy, And & Kilulya, Fidel. (2014). Preliminary in vivo antitrypanosomal activity and cytotoxicity of Entada abyssinica, Securinega virosa and Ehretia amoena. 17. 37-43.
dc.identifierhttp://hdl.handle.net/20.500.11810/4937
dc.identifier.urihttp://hdl.handle.net/20.500.11810/4937
dc.languageen
dc.publisherAfrican Journals OnLine (AJOL)
dc.subjectMedicinal plants
dc.subjectantitrypanosomal activity
dc.subjectanticancer activity
dc.subjectin vivo assay
dc.subjectSRB assay
dc.subjectbioactive components
dc.titlePreliminary in vivo antitrypanosomal activity and cytotoxicity of Entada abyssinica, Securinega virosa and Ehretia amoena
dc.typeJournal Article, Peer Reviewed

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