Iodine-Catalyzed Etherification of Morroniside
| dc.creator | Sunghwa, Fortunatus | |
| dc.creator | Sakurai, Hiroaki | |
| dc.creator | Saiki, Ikuo | |
| dc.creator | Koketsu, Mamoru | |
| dc.date | 2016-07-21T18:26:16Z | |
| dc.date | 2016-07-21T18:26:16Z | |
| dc.date | 2009-09 | |
| dc.date.accessioned | 2018-03-27T08:54:57Z | |
| dc.date.available | 2018-03-27T08:54:57Z | |
| dc.description | Full text can be accessed at https://www.jstage.jst.go.jp/article/cpb/57/1/57_1_112/_pdf | |
| dc.description | In this study, we describe a highly selective etherification procedure of unprotected morroniside catalyzed by molecular iodine in acetone. The etherification reaction furnished 7-O-alkyl ether derivatives in reasonable yields within few hours under neutral conditions. Studies of the obtained products on cytotoxicity activity in colon 26-L5 cell line were examined. Among the tested compounds, 7-O-dodecylmorroniside showed moderate cytotoxic activity, having IC50 values equal to 20.9 μM. | |
| dc.identifier | Sunghwa, F., Sakurai, H., Saiki, I. and Koketsu, M., 2009. Iodine-catalyzed etherification of morroniside. Chemical and Pharmaceutical Bulletin, 57(1), pp.112-115. | |
| dc.identifier | http://hdl.handle.net/20.500.11810/3371 | |
| dc.identifier | 10.1002/chin.200936185 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11810/3371 | |
| dc.language | en | |
| dc.subject | etherification | |
| dc.subject | Morroniside | |
| dc.subject | Cytotoxicity | |
| dc.title | Iodine-Catalyzed Etherification of Morroniside | |
| dc.type | Journal Article |