Preparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique

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dc.creatorLabuschagne, P. W.
dc.creatorAdami, R.
dc.creatorLiparoti, S.
dc.creatorNaidoo, S.
dc.creatorReverchon, E.
dc.creatorSwai, Hulda
dc.date2019-10-16T06:35:05Z
dc.date2019-10-16T06:35:05Z
dc.date2014-11
dc.date.accessioned2022-10-25T09:20:34Z
dc.date.available2022-10-25T09:20:34Z
dc.descriptionResearch Article published by Elsevier Volume 95
dc.descriptionIn this work supercritical assisted atomization (SAA) process was used for the co-precipitation of poly(d,l-lactide) (PDLLA) and rifampicin (RIF) as nanoparticles for sustained release applications. The effect of the variation of PDLLA/RIF ratio on co-precipitate characteristics was mainly investigated. The precipitated particles were analyzed in terms of their morphological, thermodynamic and crystallographic properties. In addition, loading efficiency and in-vitro release studies were conducted. Spherical PDLLA/RIF nanoparticles with mean diameter ranging from 123 to 148 nm were prepared. Loading efficiency was greater than 100% resulting in RIF loadings of 28.8 to 50.5%. X-ray diffraction revealed that the encapsulated RIF is in an amorphous state, while NMR spectra indicated no structural modifications after the SAA process. In-vitro release studies showed an initial burst release of 80–87% of total RIF loaded, necessary to suppress the generation of resistance by the microorganism, followed by first-order sustained release between 0.4 and 0.8 mg/L RIF per day over a period of 17 days.
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dc.identifierhttps://doi.org/10.1016/j.supflu.2014.08.004
dc.identifierhttp://dspace.nm-aist.ac.tz/handle/123456789/487
dc.identifier.urihttp://hdl.handle.net/123456789/95057
dc.languageen
dc.publisherElsevier
dc.subjectSupercritical assisted atomization (SAA)
dc.subjectNano-encapsulation
dc.titlePreparation of rifampicin/poly(d,l-lactice) nanoparticles for sustained release by supercritical assisted atomization technique
dc.typeArticle

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