Accuracy of giant African pouched rats for diagnosing tuberculosis: comparison with culture and Xpert W MTB/RIF

Simple item page
dc.creatorMulder, C.
dc.creatorMgode, G. F.
dc.creatorEllis, H.
dc.creatorValverde, E.
dc.creatorBeyene, N.
dc.creatorCox, C.
dc.creatorReid, S. E.
dc.creatorVan’t Hoog, A. H.
dc.creatorEdwards, T. L.
dc.date2020-06-02T11:26:38Z
dc.date2020-06-02T11:26:38Z
dc.date2017
dc.date.accessioned2022-10-25T08:53:05Z
dc.date.available2022-10-25T08:53:05Z
dc.descriptionThe International Journal of Tuberculosis and Lung Disease 21(11):pg. 1127–1133
dc.descriptionS E T T I N G : Enhanced tuberculosis (TB) case finding using detection rats in Tanzania. O B J E C T I V E S : To assess the diagnostic accuracy of detection rats compared with culture and Xpert w MTB/ RIF, and to compare enhanced case-finding algorithms using rats in smear-negative presumptive TB patients. D E S I G N : A fully paired diagnostic accuracy study in which sputum of new adult presumptive TB patients in Tanzania was tested using smear microscopy, 11 detection rats, culture and Xpert. R E S U LT S : Of 771 eligible participants, 345 (45%) were culture-positive for Mycobacterium tuberculosis, and 264 (34%) were human immunodeficiency virus (HIV) positive. The sensitivity of the detection rats was up to 75.1% (95%CI 70.1–79.5) when compared with cul- ture, and up to 81.8% (95%CI 76.0–86.5) when compared with Xpert, which was statistically signifi- cantly higher than the sensitivity of smear microscopy. Corresponding specificity was 40.6% (95%CI 35.9– 45.5) compared with culture. The accuracy of rat detection was independent of HIV status. Using rats for triage, followed by Xpert, would result in a statistically higher yield than rats followed by light- emitting diode fluorescence microscopy, whereas the number of false-positives would be significantly lower than when using Xpert alone. C O N C L U S I O N : Although detection rats did not meet the accuracy criteria as standalone diagnostic or triage testing for presumptive TB, they have additive value as a triage test for enhanced case finding among smear- negative TB patients if more advanced diagnostics are not available
dc.formatapplication/pdf
dc.identifierhttps://www.suaire.sua.ac.tz/handle/123456789/3072
dc.identifier.urihttp://hdl.handle.net/123456789/93346
dc.languageen
dc.publisherResearchgate
dc.subjectDiagnostic
dc.subjectOlfactory detection
dc.subjectCriceto- mys ansorgei
dc.subjectSensitivity
dc.subjectSpecificity
dc.titleAccuracy of giant African pouched rats for diagnosing tuberculosis: comparison with culture and Xpert W MTB/RIF
dc.typeArticle

Files

Collections

Sokoine University