A Dissertation Submitted in Partial/Fulfillment of the Requirements for Award of the Degree of Master of Business Administration in Corporate Management (MBA- CM) of Mzumbe University.The use of electronic payment has marked an impressive growth worldwide with the view to simplify and ease business transaction payments. Development in ICT is attributed to this growth. The general objective of this study is to examine the factors that influence the use of electronic payment systems among bank customers using NMB bank as a case study. A cross-sectional mixed research design that includes both qualitative and quantitative data collection and analysis techniques were employed. The study was conducted in the Dar es Salaam region and a total of 250 bank customers were sampled conveniently. The study used a structured questionnaire to collect the responses from the sampled customers. A total of 6 NMB bank branches in Dar es Salaam were surveyed. The study employed a simple multiple regression technique to analyze the factors that influence the use of the electronic payment system among banking industry customers. The dependent variable for this study was the use of electronic payment system. The independent variables include; security-related matters and the ICT know-how. The control variables include education, age, and experience. The study used SPSS version 20 for the analysis. The findings revealed that ICT know-how has a positive significant effect on the use of e-payment systems among bank customers. Furthermore, security-related matters were observed to have a negative significant effect on the use of the e-payment system among bank customers. Furthermore, findings revealed that to improve the use of e-payment system banks need to provide education to the public on the use of e-payment systems, promote internet banking, and improve TISS and POS systems. Therefore, the study recommends that among other things banks need to improve their e-payment security system to reduce the possible security challenges to the customers. Also, the bank should improve the ICT technology that enhances the e-payment services, need to improve the TISS and POS systems, and need to educate more the public on the use of e-payment systems.