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Anticonvulsant activity of extracts of diospyros fischeri stem bark

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dc.creator Moshi, MJ
dc.creator Masimba, PJ
dc.creator Nondo, RSO
dc.creator Mbwambo, ZH
dc.creator Kapingu, MC
dc.creator Mohamed, Makuru
dc.creator Kimbokota, F
dc.date 2012-10-02T12:53:51Z
dc.date 2012-10-02T12:53:51Z
dc.date 2007
dc.date.accessioned 2019-12-06T11:25:06Z
dc.date.available 2019-12-06T11:25:06Z
dc.identifier http://hdl.handle.net/123456789/80
dc.identifier.uri http://hdl.handle.net/123456789/14746
dc.description Afr J Tradit Complement Altern Med. (2007) 4(1): 94–98.
dc.description Evaluation of extracts of Diospyros fischeri Gurke (Ebenaceae), which is used traditionally for the treatment of epilepsy shows that the aqueous extract of the tem bark has no effect against picrotoxin induced convulsions in mice. However, an 80% ethanol extract of the bark caused dose‐dependent suppression of convulsions induced by 10 mg/kg body wt picrotoxin, , at doses between 100‐3200 mg/kg body wt. Petroleum ether, 1:1 dichloromethane:methanol, and methanol extracts also suppressed picrotoxin‐induced convulsions, but had a slightly lower inhibitory effect. The petroleum ether extract was the most active, but all were less active than the ethanol extract. Unlike phenobarbitone, which at 50 mg/kg body wt completely suppressed convulsions induced by 10 mg/kg body wt picrotoxin, none of the plant extracts completely suppressed convulsions in the mice. These results support the traditional uses of D.fischeri for the treatment of epilepsy. Given the seemingly innocuous nature of the extracts more work is suggested to ascertain their clinical application.
dc.format application/pdf
dc.language en
dc.subject Diospyros fischeri
dc.subject Picrotoxin
dc.subject Anti‐convulsant activity
dc.title Anticonvulsant activity of extracts of diospyros fischeri stem bark
dc.type Article


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