BACKGROUND -It is estimated that more than 333 million people will be living with diabetes mellitus by 2025. The lifetime risk of a person with diabetes developing foot ulceration is reported to be as high as 25% and it is estimated that more than a million people with diabetes require limb amputation each year, suggesting that one major amputation is performed worldwide every 30 seconds. Lower extremity minor and major amputations represent a major source of disability in patients with diabetes. Approximately 40-60 per cent of all non-traumatic amputations of the lower leg are performed on patients with diabetes.9, 11 OBJECTVES – To determine the risk factors for lower-extremity amputation (LEA) in individuals with diabetes foot and factors influencing post amputation outcomes at KCMC hospital from October 2009 to May 2010. PATIENTS AND METHOD – this study was a prospective descriptive hospital based study and 47 seven patients were enrolled with diabetic foot. RESULTS. All patients enrolled were of type 2 DM, with youngest and oldest age of 37 and 89 years consecutively. Most patients had no adequate knowledge of foot care and had uncontrolled fasting blood sugar on admission. Majority of the patients had inadequate diabetic wound care in peripheral health facilities, hence presented with an advanced stage of diabetic foot. There was high rate of amputation (83.3%) among patient admitted with diabetic foot at KCMC Hospital. Overall in-hospital mortality was 23%, and post amputation mortality of 17.1%. Sepsis and re-amputation rate were 34.3% and 20% respectively. Factors identified to be associated with amputation were duration of diabetic foot, stage of wound as per Wagner classification and age of patient. Factors predicting outcome of amputation were knowledge of diabetic foot care age of patient and ASA classification of patients.