The study intended to assess sorghum production responses through multiple uses promotion strategies. The inspiration of this study was inadequately information on how much sorghum can be put into multiple uses thus can be used as a pull factor in increasing smallholder’s production. Specific objectives were (i) examine multiple uses of sorghum in each district, (ii) determine the influence of sorghum multiple uses on sorghum production and (iii) predict future production of sorghum based on the previously production. This study was conducted in five districts namely Kongwa, Singida Rural, Iramba, Kondoa and Serengeti. Primary data and time series data were used. About 508 smallholder farmers were interviewed for this study were descriptive statistics, multiple liner regression and liner form of ARIMA model were used. The result shows that, uses of sorghum vary significantly in the five districts surveyed. Majority of respondent in all districts use sorghum for human food specifically stiff porridge (87.25%), animal feed (80.87%) and porridge (57.39%) while few responses have been observed on uses such as alcoholic brew (36.82%), non alcoholic drinks (23.77%) and (2.32%) on fried products. In terms of food utilization like stiff porridge Serengeti is the leading district followed by Kondoa and Singida. Multiple regression model reveal that, amount sold, amount used in stiff porridge, porridge, and mixed sorghum flour with other cereal are statistically significance at (p<0.00 and p<0.05) levels while local brew and other uses are not statistically. Future production of sorghum was expected to increase up 911 530 tonnes by year 2025 showing a positive increasing trend. The forecasted yield would be helpful for policy maker and sorghum stakeholder to foreseen future requirements of grain. The study concluded that, sorghum utilization in food consumption and amount sold are the major uses that influence small holder production, so more effort, support and motivation to farmers is needed so as to make sorghum as profitable crop.International Crop Research Institute for Semi Arid Tropics (ICRISAT)