| dc.creator |
Munisi, David |
|
| dc.creator |
Buza, Joram |
|
| dc.creator |
Mpolya, Emanuel |
|
| dc.creator |
Teckla, Angelo |
|
| dc.creator |
Kinung’hi, Safari |
|
| dc.date |
2019-05-21T10:41:17Z |
|
| dc.date |
2019-05-21T10:41:17Z |
|
| dc.date |
2017-09-28 |
|
| dc.date.accessioned |
2022-10-25T09:15:56Z |
|
| dc.date.available |
2022-10-25T09:15:56Z |
|
| dc.identifier |
https://doi.org/10.1155/2017/7035025 |
|
| dc.identifier |
http://dspace.nm-aist.ac.tz/handle/123456789/117 |
|
| dc.identifier.uri |
http://hdl.handle.net/123456789/94708 |
|
| dc.description |
Research Article published by BioMed Research International |
|
| dc.description |
Administeringmore than one treatmentmay increase Praziquantel cure and egg reduction rates, thereby hastening achievement of
schistosomiasis transmission control. A total of 431 S. mansoni-infected schoolchildren were randomized to receive either a single
or repeated 40mg/kg Praziquantel dose. Heights, weights, and haemoglobin levels were determined using a stadiometer, weighing
scale, and HemoCue, respectively. At 8 weeks, cure rate was higher on repeated dose (93.10%) compared to single dose (68.68%)
(𝑝 < 0.001).Theegg reduction rate was higher on repeated dose (97.54%) compared to single dose (87.27%) (𝑝 = 0.0062).Geometric
mean egg intensity was lower among those on repeated dose (1.30 epg) compared to single dose (3.18 epg) (𝑝 = 0.036) but not at 5
(𝑝 > 0.05) and 8 (𝑝 > 0.05) months with no difference in reinfection rate. No difference in the prevalence of stunting was observed
between the two treatment regimens (𝑝 > 0.05) at 8 months, but there was an increase in the prevalence of wasting among those on
repeated dose (𝑝 < 0.001). There was an increase in the mean haemoglobin levels at 8 months with no difference between the two
arms (𝑝 > 0.05). To achieve reduction of transmission intensity and disease control in highly endemic areas, repeated treatments
alone may not be sufficient.This trial was registered with PACTR201601001416338. |
|
| dc.format |
application/pdf |
|
| dc.language |
en_US |
|
| dc.publisher |
BioMed Research International |
|
| dc.subject |
Research Subject Categories |
|
| dc.title |
The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania |
|
| dc.type |
Article |
|